| Tag |
Content |
| dbPAF ID |
dbPAF-0001619 |
| Uniprot Accession |
O43708; MAAI_HUMAN; A6NED0; A6NNB8; A8MWD7; B2RCK3; O15308; O75430; Q6IB17; Q7Z610; Q9BV63;
|
| Genbank Protein ID |
NP_001299589.1; NP_665877.1; NP_665878.2; XP_005267616.1;
|
| Genbank Nucleotide ID |
NM_001312660.1; NM_145870.2; NM_145871.2; XM_005267559.2;
|
| Protein Name |
Maleylacetoacetate isomerase |
| Protein Synonyms/Alias |
|
| Gene Name |
GSTZ1 |
| Gene Synonyms/Alias |
MAAI; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.Functional Description
Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 61 | NPMKQVPTLKIDGIT | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MQAGKPILYS YFRSSCSWRV RIALALKGID YKTVPINLIK DRGQQFSKDF QALNPMKQVP 60
TLKIDGITIH QSLAIIEYLE EMRPTPRLLP QDPKKRASVR MISDLIAGGI QPLQNLSVLK 120
QVGEEMQLTW AQNAITCGFN ALEQILQSTA GIYCVGDEVT MADLCLVPQV ANAERFKVDL 180
TPYPTISSIN KRLLVLEAFQ VSHPCRQPDT PTELRA
217Fasta Sequence
>O43708|GSTZ1|Homo sapiens(Human)
MQAGKPILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKDRGQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0413--Isomerase
KW-0511--Multifunctional enzyme
KW-0585--Phenylalanine catabolism
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0828--Tyrosine catabolism
|
| Interpro |
IPR010987--Glutathione-S-Trfase_C-like
IPR004045--Glutathione_S-Trfase_N
IPR005955--Mal_ac_isom
IPR012336--Thioredoxin-like_fold
|
| PROSITE |
PS50405--GST_CTER
PS50404--GST_NTER
|
| Pfam |
PF13417--GST_N_3
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0004602--F:glutathione peroxidase activity
GO:0004364--F:glutathione transferase activity
GO:0016034--F:maleylacetoacetate isomerase activity
GO:0042803--F:protein homodimerization activity
GO:0034641--P:cellular nitrogen compound metabolic process
GO:1901687--P:glutathione derivative biosynthetic process
GO:0006749--P:glutathione metabolic process
GO:0006559--P:L-phenylalanine catabolic process
GO:0055114--P:oxidation-reduction process
GO:0044281--P:small molecule metabolic process
GO:0006572--P:tyrosine catabolic process
GO:0006805--P:xenobiotic metabolic process
|
