dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0001617 |
| Uniprot Accession | O43704; ST1B1_HUMAN; O15497; Q96FI1; Q9UK34; |
| Genbank Protein ID | NP_055280.2; XP_005265734.1; |
| Genbank Nucleotide ID | NM_014465.3; XM_005265677.2; |
| Protein Name | Sulfotransferase family cytosolic 1B member 1 |
| Protein Synonyms/Alias | |
| Gene Name | SULT1B1 |
| Gene Synonyms/Alias | ST1B2;SULT1B2; |
| Organism | Homo sapiens(Human) |
| NCBI Taxa ID | 9606 |
| Functional Description (View all) |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. |
| Phosphorylation Sites |
dbPAF PTMs: 3 |
| Sequence (Fasta) | MLSPKDILRK DLKLVHGYPM TCAFASNWEK IEQFHSRPDD IVIATYPKSG TTWVSEIIDM 60 ILNDGDIEKC KRGFITEKVP MLEMTLPGLR TSGIEQLEKN PSPRIVKTHL PTDLLPKSFW 120 ENNCKMIYLA RNAKDVSVSY YHFDLMNNLQ PFPGTWEEYL EKFLTGKVAY GSWFTHVKNW 180 WKKKEEHPIL FLYYEDMKEN PKEEIKKIIR FLEKNLNDEI LDRIIHHTSF EVMKDNPLVN 240 YTHLPTTVMD HSKSPFMRKG TAGDWKNYFT VAQNEKFDAI YETEMSKTAL QFRTEI 297 |
| Keyword | KW-0002--3D-structure |
| Interpro | |
| PROSITE | |
| Pfam | PF00685--Sulfotransfer_1 |
| Gene Ontology | GO:0005829--C:cytosol |