dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001616
Uniprot Accession O43699; SIGL6_HUMAN; A8MV71; B2RTS8; C9JBE5; F8WA78; O15388; O43700;
Genbank Protein ID NP_001171018.1; NP_001171019.1; NP_001171020.1; NP_001236.4; NP_942142.3; NP_942143.3;
Genbank Nucleotide ID NM_001177547.1; NM_001177548.1; NM_001177549.1; NM_001245.5; NM_198845.4; NM_198846.4;
Protein Name Sialic acid-binding Ig-like lectin 6
Protein Synonyms/Alias
Gene Name SIGLEC6
Gene Synonyms/Alias CD33L;CD33L1;OBBP1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
107RRKNCSLSIRDARRRPhosphoSitePlus22135298
426EDEQELHYAVLHFHKPhosphoSitePlus22135298
446PKVTDTEYSEIKIHKPhosphoSitePlus22135298
Sequence
(Fasta)		MQGAQEASAS EMLPLLLPLL WAGALAQERR FQLEGPESLT VQEGLCVLVP CRLPTTLPAS 60
YYGYGYWFLE GADVPVATND PDEEVQEETR GRFHLLWDPR RKNCSLSIRD ARRRDNAAYF 120
FRLKSKWMKY GYTSSKLSVR VMALTHRPNI SIPGTLESGH PSNLTCSVPW VCEQGTPPIF 180
SWMSAAPTSL GPRTTQSSVL TITPRPQDHS TNLTCQVTFP GAGVTMERTI QLNVSYAPQK 240
VAISIFQGNS AAFKILQNTS SLPVLEGQAL RLLCDADGNP PAHLSWFQGF PALNATPISN 300
TGVLELPQVG SAEEGDFTCR AQHPLGSLQI SLSLFVHWKP EGRAGGVLGA VWGASITTLV 360
FLCVCFIFRV KTRRKKAAQP VQNTDDVNPV MVSGSRGHQH QFQTGIVSDH PAEAGPISED 420
EQELHYAVLH FHKVQPQEPK VTDTEYSEIK IHK 454
Keyword

KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0393--Immunoglobulin domain
KW-0430--Lectin
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR003006--Ig/MHC_CS
IPR013098--Ig_I-set
IPR003599--Ig_sub
IPR003598--Ig_sub2
IPR013106--Ig_V-set
IPR013151--Immunoglobulin
PROSITE

PS50835--IG_LIKE
PS00290--IG_MHC
Pfam

PF07679--I-set
PF00047--ig
PF07686--V-set
Gene Ontology

GO:0005576--C:extracellular region
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0030246--F:carbohydrate binding
GO:0007155--P:cell adhesion
GO:0007267--P:cell-cell signaling