dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001614
Uniprot Accession O43688; LPP2_HUMAN; A6NLV0; E9PAY8;
Genbank Protein ID NP_003703.1; NP_803545.1; NP_808211.1;
Genbank Nucleotide ID NM_003712.3; NM_177526.2; NM_177543.2;
Protein Name Lipid phosphate phosphohydrolase 2
Protein Synonyms/Alias PAP2-gamma;PAP2-G;Phosphatidate phosphohydrolase type 2c;Phosphatidic acid phosphatase 2c;PAP-2c;PAP2c;
Gene Name PPAP2C
Gene Synonyms/Alias LPP2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
63LMAGVTITATVILVScurated25262027
65AGVTITATVILVSAGcurated25262027
75LVSAGEAYLVYTDRLcurated25262027
78AGEAYLVYTDRLYSRcurated25262027
79GEAYLVYTDRLYSRScurated25262027
91SRSDFNNYVAAVYKVdbPTM 3.0;PhosphoSitePlus18083107; 16381945; 23193290; 22135298
109FLFGAAVSQSLTDLAdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
118SLTDLAKYMIGRLRPPhosphoSitePlus22135298
266EELERKPSLSLTLTLdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;curated17081983; 16381945; 23193290; 21081558; 22135298; 25627689;
268LERKPSLSLTLTLGEPhosphoSitePlus;curated22135298; 25627689; 20873877
270RKPSLSLTLTLGEADdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 22135298; 19366988;
272PSLSLTLTLGEADHNPhosphoSitePlus;curated22135298; 25627689
281GEADHNHYGYPHSSSdbPTM 3.0;PhosphoSitePlus18180459; 20736484; 16381945; 23193290; 22135298
283ADHNHYGYPHSSS--dbPTM 3.0;PhosphoSitePlus18180459; 16381945; 23193290; 22135298
286NHYGYPHSSS-----PhosphoSitePlus;curated22135298; 25627689
287HYGYPHSSS------PhosphoSitePlus22135298
288YGYPHSSS-------PhosphoSitePlus22135298
Sequence
(Fasta)		MQRRWVFVLL DVLCLLVASL PFAILTLVNA PYKRGFYCGD DSIRYPYRPD TITHGLMAGV 60
TITATVILVS AGEAYLVYTD RLYSRSDFNN YVAAVYKVLG TFLFGAAVSQ SLTDLAKYMI 120
GRLRPNFLAV CDPDWSRVNC SVYVQLEKVC RGNPADVTEA RLSFYSGHSS FGMYCMVFLA 180
LYVQARLCWK WARLLRPTVQ FFLVAFALYV GYTRVSDYKH HWSDVLVGLL QGALVAALTV 240
CYISDFFKAR PPQHCLKEEE LERKPSLSLT LTLGEADHNH YGYPHSSS 289
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR028674--LPP2
IPR000326--P_Acid_Pase_2/haloperoxidase
PROSITE
Pfam

PF01569--PAP2
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0042577--F:lipid phosphatase activity
GO:0008195--F:phosphatidate phosphatase activity
GO:0004721--F:phosphoprotein phosphatase activity
GO:0046839--P:phospholipid dephosphorylation
GO:0006644--P:phospholipid metabolic process
GO:0006470--P:protein dephosphorylation
GO:0007165--P:signal transduction
GO:0044281--P:small molecule metabolic process
GO:0030148--P:sphingolipid biosynthetic process
GO:0006665--P:sphingolipid metabolic process