dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001613
Uniprot Accession O43687; AKA7A_HUMAN; A8K2K6; Q5TBR9; Q5TBS0; Q9HCZ8; Q9P0G4;
Genbank Protein ID NP_004833.1; NP_619539.1;
Genbank Nucleotide ID NM_004842.3; NM_138633.2;
Protein Name A-kinase anchor protein 7 isoforms alpha and beta
Protein Synonyms/Alias
Gene Name AKAP7
Gene Synonyms/Alias AKAP15;AKAP18;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
17SRDEGKISELESSSSPhosphoSitePlus22135298
22KISELESSSSAVLQRPhosphoSitePlus22135298
Sequence
(Fasta)		MGQLCCFPFS RDEGKISELE SSSSAVLQRY SKDIPSWSSG EKNGGEPDDA ELVRLSKRLV 60
ENAVLKAVQQ YLEETQNKNK PGEGSSVKTE AADQNGNDNE NNRK 105
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0564--Palmitate
KW-1185--Reference proteome
Interpro

IPR019511--AKAP7_RI-RII-bd_dom
PROSITE
Pfam

PF10470--AKAP7_RIRII_bdg
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005622--C:intracellular
GO:0016328--C:lateral plasma membrane
GO:0005886--C:plasma membrane
GO:0051018--F:protein kinase A binding
GO:0001508--P:action potential
GO:0071320--P:cellular response to cAMP
GO:0035556--P:intracellular signal transduction
GO:0006811--P:ion transport
GO:1902261--P:positive regulation of delayed rectifier potassium channel activity
GO:1901381--P:positive regulation of potassium ion transmembrane transport
GO:0008104--P:protein localization
GO:0060306--P:regulation of membrane repolarization