| Tag |
Content |
| dbPAF ID |
dbPAF-0001609 |
| Uniprot Accession |
O43680; TCF21_HUMAN; E1P581; O43545; Q6ICV0; Q9BZ14;
|
| Genbank Protein ID |
NP_003197.2; NP_938206.1;
|
| Genbank Nucleotide ID |
NM_003206.3; NM_198392.2;
|
| Protein Name |
Transcription factor 21 |
| Protein Synonyms/Alias |
|
| Gene Name |
TCF21 |
| Gene Synonyms/Alias |
BHLHA23;POD1; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.Functional Description
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 140 | QILANDKYENGYIHP | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MSTGSLSDVE DLQEVEMLEC DGLKMDSNKE FVTSNESTEE SSNCENGSPQ KGRGGLGKRR 60
KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS RLKTTLPWVP PDTKLSKLDT 120
LRLASSYIAH LRQILANDKY ENGYIHPVNL TWPFMVAGKP ESDLKEVVTA SRLCGTTAS
180
Fasta Sequence
>O43680|TCF21|Homo sapiens(Human)
MSTGSLSDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPESDLKEVVTASRLCGTTAS
|
| Keyword |
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR011598--bHLH_dom
|
| PROSITE |
PS50888--BHLH
|
| Pfam |
PF00010--HLH
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0050681--F:androgen receptor binding
GO:0043425--F:bHLH transcription factor binding
GO:0070888--F:E-box binding
GO:0046983--F:protein dimerization activity
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001658--P:branching involved in ureteric bud morphogenesis
GO:0014707--P:branchiomeric skeletal muscle development
GO:0060435--P:bronchiole development
GO:0060539--P:diaphragm development
GO:0048557--P:embryonic digestive tract morphogenesis
GO:0030855--P:epithelial cell differentiation
GO:0048732--P:gland development
GO:0032835--P:glomerulus development
GO:0001822--P:kidney development
GO:0048286--P:lung alveolus development
GO:0060425--P:lung morphogenesis
GO:0060426--P:lung vasculature development
GO:0072277--P:metanephric glomerular capillary formation
GO:0072162--P:metanephric mesenchymal cell differentiation
GO:0001763--P:morphogenesis of a branching structure
GO:0060766--P:negative regulation of androgen receptor signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0060021--P:palate development
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0048608--P:reproductive structure development
GO:0060541--P:respiratory system development
GO:0060008--P:Sertoli cell differentiation
GO:0007530--P:sex determination
GO:0048536--P:spleen development
GO:0001657--P:ureteric bud development
GO:0001944--P:vasculature development
|
