dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001604
Uniprot Accession O43670; ZN207_HUMAN; A8K6Y6; E1P660; E1P661; E1P662; Q53XS9; Q96HW5; Q9BUQ7;
Genbank Protein ID NP_001027464.1; NP_001091977.1; NP_003448.1;
Genbank Nucleotide ID NM_001032293.2; NM_001098507.1; NM_003457.3;
Protein Name BUB3-interacting and GLEBS motif-containing protein ZNF207
Protein Synonyms/Alias
Gene Name ZNF207
Gene Synonyms/Alias BUGZ;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
101RRLLEQKTQESQKKKPhosphoSitePlus;curated22135298; 26074081
113KKKQQDDSDEYDDDDcurated26074081
346TAAKPAASITSKPATPhosphoSitePlus;curated22135298; 25627689
357KPATLTTTSATSKLIcurated25627689
358PATLTTTSATSKLIHcurated25627689
360TLTTTSATSKLIHPDcurated25627689
Sequence
(Fasta)		MGRKKKKQLK PWCWYCNRDF DDEKILIQHQ KAKHFKCHIC HKKLYTGPGL AIHCMQVHKE 60
TIDAVPNAIP GRTDIELEIY GMEGIPEKDM DERRRLLEQK TQESQKKKQQ DDSDEYDDDD 120
SAASTSFQPQ PVQPQQGYIP PMAQPGLPPV PGAPGMPPGI PPLMPGVPPL MPGMPPVMPG 180
MPPGMMPMGG MMPPGPGIPP LMPGMPPGMP PPVPRPGIPP MTQAQAVSAP GILNRPPAPT 240
ATVPAPQPPV TKPLFPSAGQ MGTPVTSSST ASSNSESLSA SSKALFPSTA QAQAAVQGPV 300
GTDFKPLNST PATTTEPPKP TFPAYTQSTA STTSTTNSTA AKPAASITSK PATLTTTSAT 360
SKLIHPDEDI SLEERRAQLP KYQRNLPRPG QAPIGNPPVG PIGGMMPPQP GIPQQQGMRP 420
PMPPHGQYGG HHQGMPGYLP GAMPPYGQGP PMVPPYQGGP PRPPMGMRPP VMSQGGRY 479
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0238--DNA-binding
KW-0995--Kinetochore
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0498--Mitosis
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
PROSITE

PS00028--ZINC_FINGER_C2H2_1
Pfam
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:1990047--C:spindle matrix
GO:0003677--F:DNA binding
GO:0008201--F:heparin binding
GO:0008017--F:microtubule binding
GO:0044822--F:poly(A) RNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0008608--P:attachment of spindle microtubules to kinetochore
GO:0051301--P:cell division
GO:0001578--P:microtubule bundle formation
GO:0046785--P:microtubule polymerization
GO:0000070--P:mitotic sister chromatid segregation
GO:0090307--P:mitotic spindle assembly
GO:0007094--P:mitotic spindle assembly checkpoint
GO:0050821--P:protein stabilization
GO:0051983--P:regulation of chromosome segregation
GO:0006355--P:regulation of transcription, DNA-templated