dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001603
Uniprot Accession O43665; RGS10_HUMAN; A8K408; B1AMR8; Q6IAZ6; Q96GN0;
Genbank Protein ID NP_001005339.1; NP_002916.1;
Genbank Nucleotide ID NM_001005339.1; NM_002925.3;
Protein Name Regulator of G-protein signaling 10
Protein Synonyms/Alias
Gene Name RGS10
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
13CFADIHDSDGSSSSSPhosphoSitePlus22135298
16DIHDSDGSSSSSHQSdbPTM 3.0;Phospho.ELM 9.017287340; 16381945; 23193290
19DSDGSSSSSHQSLKSPhosphoSitePlus22135298
20SDGSSSSSHQSLKSTPhosphoSitePlus22135298
23SSSSSHQSLKSTAKWPhosphoSitePlus22135298
33STAKWAASLENLLEDcurated24400094; 22199227
86QEKAKEIYMTFLSSKPhosphoSitePlus22135298
135NLMKYDSYSRFLKSDPhosphoSitePlus22135298
168QTAAKRASRIYNT--dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated11443111; 16381945; 23193290; 18988627; 22135298; 26074081
171AKRASRIYNT-----PhosphoSitePlus22135298
Sequence
(Fasta)		MQSELCFADI HDSDGSSSSS HQSLKSTAKW AASLENLLED PEGVKRFREF LKKEFSEENV 60
LFWLACEDFK KMQDKTQMQE KAKEIYMTFL SSKASSQVNV EGQSRLNEKI LEEPHPLMFQ 120
KLQDQIFNLM KYDSYSRFLK SDLFLKHKRT EEEEEDLPDA QTAAKRASRI YNT 174
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0734--Signal transduction inhibitor
Interpro

IPR016137--RGS
IPR024066--RGS_subdom1
PROSITE

PS50132--RGS
Pfam

PF00615--RGS
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0009968--P:negative regulation of signal transduction
GO:0043547--P:positive regulation of GTPase activity