dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001602
Uniprot Accession O43663; PRC1_HUMAN; A6NC44; B4DLR1; H9KV59; Q9BSB6;
Genbank Protein ID NP_001254509.1; NP_003972.1;
Genbank Nucleotide ID NM_001267580.1; NM_003981.3;
Protein Name Protein regulator of cytokinesis 1
Protein Synonyms/Alias
Gene Name PRC1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).
Phosphorylation Sites
 dbPAF PTMs: 45 (View all)
PositionPeptidesSourceReferences ( PMIDs )
4----MRRSEVLAEESPhosphoSitePlus;curated22135298; 25850435; 25627689; 23898821
105QLEKDLRTQVELMRKPhosphoSitePlus22135298
191CMEALDHTPDTSFERdbPTM 3.017081983; 16381945; 23193290
194ALDHTPDTSFERDVVdbPTM 3.0;curated20068231; 16381945; 23193290; 20873877; 23663014
195LDHTPDTSFERDVVCdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;UniProt;curated16565220; 16381945; 23193290; 17081983; 18988627; 22135298;
262EEREAVATIMSGSKAPhosphoSitePlus22135298
265EAVATIMSGSKAKVRdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated19007248; 16381945; 23193290; 19691289; 20068231; 18988627;
267VATIMSGSKAKVRKAdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18452278; 16381945; 23193290; 18988627; 22135298; 25627689
379ASDPNRFTNRGGNLLPhosphoSitePlus22135298
464QTETEMLYGSAPRTPdbPTM 3.0;PhosphoSitePlus;curated21403953; 21447384; 16381945; 23193290; 22135298; 25627689;
466ETEMLYGSAPRTPSKPhosphoSitePlus;curated22135298; 25627689; 23090842
470LYGSAPRTPSKRRGLdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated9885575; 17351640; 17438553; 16381945; 23193290; 16603632; 1
472GSAPRTPSKRRGLAPPhosphoSitePlus;curated22135298; 25627689; 22199227
481RRGLAPNTPGKARKLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated9885575; 16964243; 17351640; 17438553; 18691976; 16381945; 2
501SNATANSSIRPIFGGdbPTM 3.0;HPRD 9;UniProt19007248; 16381945; 23193290; 18988627; 9885575
509IRPIFGGTVYHSPVSPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 25627689
511PIFGGTVYHSPVSRLPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
513FGGTVYHSPVSRLPPdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 19007248; 16381945; 23193290; 19691289; 20068231;
516TVYHSPVSRLPPSGSPhosphoSitePlus;curated22135298; 23186163; 21857030
521PVSRLPPSGSKPVAAPhosphoSitePlus22135298
Sequence
(Fasta)		MRRSEVLAEE SIVCLQKALN HLREIWELIG IPEDQRLQRT EVVKKHIKEL LDMMIAEEES 60
LKERLIKSIS VCQKELNTLC SELHVEPFQE EGETTILQLE KDLRTQVELM RKQKKERKQE 120
LKLLQEQDQE LCEILCMPHY DIDSASVPSL EELNQFRQHV TTLRETKASR REEFVSIKRQ 180
IILCMEALDH TPDTSFERDV VCEDEDAFCL SLENIATLQK LLRQLEMQKS QNEAVCEGLR 240
TQIRELWDRL QIPEEEREAV ATIMSGSKAK VRKALQLEVD RLEELKMQNM KKVIEAIRVE 300
LVQYWDQCFY SQEQRQAFAP FCAEDYTESL LQLHDAEIVR LKNYYEVHKE LFEGVQKWEE 360
TWRLFLEFER KASDPNRFTN RGGNLLKEEK QRAKLQKMLP KLEEELKARI ELWEQEHSKA 420
FMVNGQKFME YVAEQWEMHR LEKERAKQER QLKNKKQTET EMLYGSAPRT PSKRRGLAPN 480
TPGKARKLNT TTMSNATANS SIRPIFGGTV YHSPVSRLPP SGSKPVAAST CSGKKTPRTG 540
RHGANKENLE LNGSILSGGY PGSAPLQRNF SINSVASTYS EFAKDPSLSD SSTVGLQREL 600
SKASKSDATS GILNSTNIQS 621
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0539--Nucleus
KW-0553--Oncogene
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR007145--MAP65_Ase1_PRC1
PROSITE
Pfam

PF03999--MAP65_ASE1
Gene Ontology

GO:0070938--C:contractile ring
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0015630--C:microtubule cytoskeleton
GO:0030496--C:midbody
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005819--C:spindle
GO:0005876--C:spindle microtubule
GO:0000922--C:spindle pole
GO:0042802--F:identical protein binding
GO:0019894--F:kinesin binding
GO:0019901--F:protein kinase binding
GO:0000910--P:cytokinesis
GO:0000022--P:mitotic spindle elongation
GO:0008284--P:positive regulation of cell proliferation
GO:0007264--P:small GTPase mediated signal transduction