dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001601
Uniprot Accession O43660; PLRG1_HUMAN; B3KMK4; Q3KQY5; Q8WUD8;
Genbank Protein ID NP_001188493.1; NP_002660.1;
Genbank Nucleotide ID NM_001201564.1; NM_002669.3;
Protein Name Pleiotropic regulator 1
Protein Synonyms/Alias
Gene Name PLRG1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
Phosphorylation Sites
dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
52AIKLRNEYGPVLHMPdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated21394647; 16381945; 23193290; 21081558; 22135298; 25627689
92NQGQEVEYFVAGTHPdbPTM 3.0;HPRD 9;PhosphoSitePlus17360941; 20562096; 16381945; 23193290; 18452278; 18988627;
97VEYFVAGTHPYPPGPPhosphoSitePlus22135298
119TKIQRMPSESAAQSLdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
121IQRMPSESAAQSLAVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689
125PSESAAQSLAVALPLPhosphoSitePlus22135298
175ETGNTKNSALMAKKAPhosphoSitePlus22135298
184LMAKKAPTMPKPQWHPhosphoSitePlus22135298
201WKLYRVISGHLGWVRPhosphoSitePlus;curated22135298; 23186163
277VKCWDLEYNKVIRHYPhosphoSitePlus22135298
389PRHYTFASGSPDNIKPhosphoSitePlus;curated22135298; 25627689
391HYTFASGSPDNIKQWPhosphoSitePlus;curated22135298; 23186163; 25849741
Sequence
(Fasta)
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT 60
SKENLKEKGP QNATDSYVHK QYPANQGQEV EYFVAGTHPY PPGPGVALTA DTKIQRMPSE 120
SAAQSLAVAL PLQTKADANR TAPSGSEYRH PGASDRPQPT AMNSIVMETG NTKNSALMAK 180
KAPTMPKPQW HPPWKLYRVI SGHLGWVRCI AVEPGNQWFV TGSADRTIKI WDLASGKLKL 240
SLTGHISTVR GVIVSTRSPY LFSCGEDKQV KCWDLEYNKV IRHYHGHLSA VYGLDLHPTI 300
DVLVTCSRDS TARIWDVRTK ASVHTLSGHT NAVATVRCQA AEPQIITGSH DTTIRLWDLV 360
AGKTRVTLTN HKKSVRAVVL HPRHYTFASG SPDNIKQWKF PDGSFIQNLS GHNAIINTLT 420
VNSDGVLVSG ADNGTMHLWD WRTGYNFQRV HAAVQPGSLD SESGIFACAF DQSESRLLTA 480
EADKTIKVYR EDDTATEETH PVSWKPEIIK RKRF 515
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0031965--C:nuclear membrane
GO:0016607--C:nuclear speck
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0071011--C:precatalytic spliceosome
GO:0000974--C:Prp19 complex
GO:0010467--P:gene expression
GO:0000398--P:mRNA splicing, via spliceosome
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0034504--P:protein localization to nucleus
GO:0008380--P:RNA splicing