Tag |
Content |
dbPAF ID |
dbPAF-0001601 |
Uniprot Accession |
O43660; PLRG1_HUMAN; B3KMK4; Q3KQY5; Q8WUD8; |
Genbank Protein ID |
NP_001188493.1; NP_002660.1; |
Genbank Nucleotide ID |
NM_001201564.1; NM_002669.3; |
Protein Name |
Pleiotropic regulator 1 |
Protein Synonyms/Alias |
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Gene Name |
PLRG1 |
Gene Synonyms/Alias |
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Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.Functional Description
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
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Phosphorylation Sites
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dbPAF PTMs: 12 |
Sequence (Fasta) | MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT 60 SKENLKEKGP QNATDSYVHK QYPANQGQEV EYFVAGTHPY PPGPGVALTA DTKIQRMPSE 120 SAAQSLAVAL PLQTKADANR TAPSGSEYRH PGASDRPQPT AMNSIVMETG NTKNSALMAK 180 KAPTMPKPQW HPPWKLYRVI SGHLGWVRCI AVEPGNQWFV TGSADRTIKI WDLASGKLKL 240 SLTGHISTVR GVIVSTRSPY LFSCGEDKQV KCWDLEYNKV IRHYHGHLSA VYGLDLHPTI 300 DVLVTCSRDS TARIWDVRTK ASVHTLSGHT NAVATVRCQA AEPQIITGSH DTTIRLWDLV 360 AGKTRVTLTN HKKSVRAVVL HPRHYTFASG SPDNIKQWKF PDGSFIQNLS GHNAIINTLT 420 VNSDGVLVSG ADNGTMHLWD WRTGYNFQRV HAAVQPGSLD SESGIFACAF DQSESRLLTA 480 EADKTIKVYR EDDTATEETH PVSWKPEIIK RKRF
515Fasta Sequence
>O43660|PLRG1|Homo sapiens(Human) MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPTSKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSESAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPEIIKRKRF
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Keyword |
KW-0002--3D-structure KW-0007--Acetylation KW-0025--Alternative splicing KW-0181--Complete proteome KW-0903--Direct protein sequencing KW-0507--mRNA processing KW-0508--mRNA splicing KW-0539--Nucleus KW-1185--Reference proteome KW-0677--Repeat KW-0747--Spliceosome KW-0853--WD repeat
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Interpro |
IPR020472--G-protein_beta_WD-40_rep IPR015943--WD40/YVTN_repeat-like_dom IPR001680--WD40_repeat IPR019775--WD40_repeat_CS IPR017986--WD40_repeat_dom
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PROSITE |
PS00678--WD_REPEATS_1 PS50082--WD_REPEATS_2 PS50294--WD_REPEATS_REGION
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Pfam |
PF00400--WD40
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Gene Ontology |
GO:0071013--C:catalytic step 2 spliceosome GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex GO:0031965--C:nuclear membrane GO:0016607--C:nuclear speck GO:0005730--C:nucleolus GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0071011--C:precatalytic spliceosome GO:0000974--C:Prp19 complex GO:0010467--P:gene expression GO:0000398--P:mRNA splicing, via spliceosome GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle GO:0034504--P:protein localization to nucleus GO:0008380--P:RNA splicing
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