dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001597
Uniprot Accession O43633; CHM2A_HUMAN; B2R4W6; Q3ZTT0;
Genbank Protein ID NP_055268.1; NP_940818.1;
Genbank Nucleotide ID NM_014453.3; NM_198426.2;
Protein Name Charged multivesicular body protein 2a
Protein Synonyms/Alias Chromatin-modifying protein 2a;CHMP2a;Putative breast adenocarcinoma marker BC-2;Vacuolar protein sorting-associated protein 2-1;Vps2-1;hVps2-1;
Gene Name CHMP2A
Gene Synonyms/Alias BC2;CHMP2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
10LLFGRRKTPEELLRQPhosphoSitePlus;curated22135298; 23186163; 21857030
38RERQKLETQEKKIIAdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
87RANIQAVSLKIQTLKPhosphoSitePlus22135298
92AVSLKIQTLKSNNSMPhosphoSitePlus22135298
95LKIQTLKSNNSMAQAPhosphoSitePlus;curated22135298; 25627689
98QTLKSNNSMAQAMKGcurated22817900
174VLDELGLSLTDELSNPhosphoSitePlus22135298
180LSLTDELSNLPSTGGPhosphoSitePlus22135298
184DELSNLPSTGGSLSVPhosphoSitePlus;UniProt22135298; 24275569
185ELSNLPSTGGSLSVAPhosphoSitePlus;UniProt22135298; 24275569
188NLPSTGGSLSVAAGGPhosphoSitePlus;UniProt22135298; 24275569
190PSTGGSLSVAAGGKKPhosphoSitePlus;UniProt22135298; 24275569
203KKAEAAASALADADAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16565220; 16381945; 23193290; 18988627; 19060867; 22135298;
Sequence
(Fasta)		MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR 60
IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP 120
QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS 180
NLPSTGGSLS VAAGGKKAEA AASALADADA DLEERLKNLR RD 223
Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR005024--Snf7_fam
PROSITE
Pfam

PF03357--Snf7
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031902--C:late endosome membrane
GO:0016020--C:membrane
GO:0030117--C:membrane coat
GO:0031210--F:phosphatidylcholine binding
GO:0019904--F:protein domain specific binding
GO:0000920--P:cell separation after cytokinesis
GO:0016197--P:endosomal transport
GO:0045184--P:establishment of protein localization
GO:0010324--P:membrane invagination
GO:0061024--P:membrane organization
GO:0007080--P:mitotic metaphase plate congression
GO:0060548--P:negative regulation of cell death
GO:1903723--P:negative regulation of centriole elongation
GO:0006997--P:nucleus organization
GO:1903543--P:positive regulation of exosomal secretion
GO:1902188--P:positive regulation of viral release from host cell
GO:0006892--P:post-Golgi vesicle-mediated transport
GO:0051291--P:protein heterooligomerization
GO:0051260--P:protein homooligomerization
GO:0051258--P:protein polymerization
GO:0015031--P:protein transport
GO:0010824--P:regulation of centrosome duplication
GO:1901673--P:regulation of mitotic spindle assembly
GO:0050792--P:regulation of viral process
GO:0007034--P:vacuolar transport
GO:0039702--P:viral budding via host ESCRT complex
GO:0019058--P:viral life cycle
GO:0016032--P:viral process