Functional Description
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Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.Functional Description
Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. |
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0060536--P:cartilage morphogenesis
GO:0003273--P:cell migration involved in endocardial cushion formation
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0044344--P:cellular response to fibroblast growth factor stimulus
GO:0071479--P:cellular response to ionizing radiation
GO:0035921--P:desmosome disassembly
GO:0001837--P:epithelial to mesenchymal transition
GO:0003198--P:epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0060429--P:epithelium development
GO:2000811--P:negative regulation of anoikis
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0035414--P:negative regulation of catenin import into nucleus
GO:0006933--P:negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0033629--P:negative regulation of cell adhesion mediated by integrin
GO:1900387--P:negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
GO:0032331--P:negative regulation of chondrocyte differentiation
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:2001240--P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010839--P:negative regulation of keratinocyte proliferation
GO:2000647--P:negative regulation of stem cell proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0010957--P:negative regulation of vitamin D biosynthetic process
GO:0070563--P:negative regulation of vitamin D receptor signaling pathway
GO:0014032--P:neural crest cell development
GO:0007219--P:Notch signaling pathway
GO:0001649--P:osteoblast differentiation
GO:0060021--P:palate development
GO:0043473--P:pigmentation
GO:0030335--P:positive regulation of cell migration
GO:0045600--P:positive regulation of fat cell differentiation
GO:0035066--P:positive regulation of histone acetylation
GO:2000810--P:regulation of bicellular tight junction assembly
GO:0060693--P:regulation of branching involved in salivary gland morphogenesis
GO:0032642--P:regulation of chemokine production
GO:0045667--P:regulation of osteoblast differentiation
GO:0007605--P:sensory perception of sound
GO:0006351--P:transcription, DNA-templated
GO:0050872--P:white fat cell differentiation
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