dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001595
Uniprot Accession O43615; TIM44_HUMAN; A8K0R9; D6W664; Q8N193;
Genbank Protein ID NP_006342.2;
Genbank Nucleotide ID NM_006351.3;
Protein Name Mitochondrial import inner membrane translocase subunit TIM44
Protein Synonyms/Alias
Gene Name TIMM44
Gene Synonyms/Alias MIMT44;TIM44;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
61GNRKGFLSGLLDNVKdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
80KNKEMKESIKKFRDEcurated26074081
106EARRKYKTIESETVRPHOSIDA;curated21081558; 22817900
109RKYKTIESETVRTSEcurated26074081
111YKTIESETVRTSEVLcurated22817900; 26074081
115ESETVRTSEVLRKKLcurated26074081
128KLGELTGTVKESLHEPhosphoSitePlus;curated22135298; 23186163
159AAKTAKQSAESVSKGPhosphoSitePlus22135298
180TAAFRALSQGVESVKdbPTM 3.0;PhosphoSitePlus;UniProt;curated21406692; 16381945; 23193290; 22135298; 25850435; 25627689;
201VLGQTGPYRRPQRLRPhosphoSitePlus22135298
280IRASRALTDKVTDLLPhosphoSitePlus22135298
292DLLGGLFSKTEMSEVPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 22817900
435DQDELNPYAAWRLLDPhosphoSitePlus22135298
Sequence
(Fasta)		MAAAALRSGW CRCPRRCLGS GIQFLSSHNL PHGSTYQMRR PGGELPLSKS YSSGNRKGFL 60
SGLLDNVKQE LAKNKEMKES IKKFRDEARR LEESDVLQEA RRKYKTIESE TVRTSEVLRK 120
KLGELTGTVK ESLHEVSKSD LGRKIKEGVE EAAKTAKQSA ESVSKGGEKL GRTAAFRALS 180
QGVESVKKEI DDSVLGQTGP YRRPQRLRKR TEFAGDKFKE EKVFEPNEEA LGVVLHKDSK 240
WYQQWKDFKE NNVVFNRFFE MKMKYDESDN AFIRASRALT DKVTDLLGGL FSKTEMSEVL 300
TEILRVDPAF DKDRFLKQCE NDIIPNVLEA MISGELDILK DWCYEATYSQ LAHPIQQAKA 360
LGLQFHSRIL DIDNVDLAMG KMMEQGPVLI ITFQAQLVMV VRNPKGEVVE GDPDKVLRML 420
YVWALCRDQD ELNPYAAWRL LDISASSTEQ IL 453
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0811--Translocation
KW-0813--Transport
Interpro

IPR017303--Tim44
IPR007379--Tim44-like_dom
PROSITE
Pfam

PF04280--Tim44
Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0005524--F:ATP binding
GO:0051087--F:chaperone binding
GO:0015450--F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO:0044267--P:cellular protein metabolic process
GO:0030150--P:protein import into mitochondrial matrix
GO:0006626--P:protein targeting to mitochondrion