| Tag |
Content |
| dbPAF ID |
dbPAF-0001594 |
| Uniprot Accession |
O43614; OX2R_HUMAN; Q5VTM0;
|
| Genbank Protein ID |
NP_001517.2;
|
| Genbank Nucleotide ID |
NM_001526.3;
|
| Protein Name |
Orexin receptor type 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
HCRTR2 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.Functional Description
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MSGTKLEDSP PCRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP KEYEWVLIAG 60
YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD VLVTITCLPA TLVVDITETW 120
FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL DRWYAICHPL MFKSTAKRAR NSIVIIWIVS 180
CIIMIPQAIV MECSTVFPGL ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV 240
LAYLQIFRKL WCRQIPGTSS VVQRKWKPLQ PVSQPRGPGQ PTKSRMSAVA AEIKQIRARR 300
KTARMLMIVL LVFAICYLPI SILNVLKRVF GMFAHTEDRE TVYAWFTFSH WLVYANSAAN 360
PIIYNFLSGK FREEFKAAFS CCCLGVHHRQ EDRLTRGRTS TESRKSLTTQ ISNFDNISKL 420
SEQVVLTSIS TLPAANGAGP LQNW
445Fasta Sequence
>O43614|HCRTR2|Homo sapiens(Human)
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
|
| Keyword |
KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
IPR000204--Orexin_rcpt
IPR004060--Orexin_rcpt_2
|
| PROSITE |
PS00237--G_PROTEIN_RECEP_F1_1
PS50262--G_PROTEIN_RECEP_F1_2
|
| Pfam |
PF00001--7tm_1
PF03827--Orexin_rec2
|
| Gene Ontology |
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0008188--F:neuropeptide receptor activity
GO:0016499--F:orexin receptor activity
GO:0042277--F:peptide binding
GO:0017046--F:peptide hormone binding
GO:0032870--P:cellular response to hormone stimulus
GO:0022410--P:circadian sleep/wake cycle process
GO:0007631--P:feeding behavior
GO:0007218--P:neuropeptide signaling pathway
GO:0007200--P:phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0045187--P:regulation of circadian sleep/wake cycle, sleep
GO:1901652--P:response to peptide
GO:0007268--P:synaptic transmission
|
