dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001593
Uniprot Accession O43613; OX1R_HUMAN; A8K3A6; Q9HBV6;
Genbank Protein ID NP_001516.2; XP_011539610.1;
Genbank Nucleotide ID NM_001525.2; XM_011541308.1;
Protein Name Orexin receptor type 1
Protein Synonyms/Alias
Gene Name HCRTR1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
27PSPVPPDYEDEFLRYdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18083107; 16381945; 23193290; 18988627; 22135298; 22817900
34YEDEFLRYLWRDYLYcurated26074081
39LRYLWRDYLYPKQYEcurated26074081
41YLWRDYLYPKQYEWVcurated26074081
83HMRTVTNYFIVNLSLdbPTM 3.0;PhosphoSitePlus;curated19661287; 16381945; 23193290; 22135298; 22817900
124ALCKVIPYLQAVSVSPhosphoSitePlus22135298
138SVAVLTLSFIALDRWPhosphoSitePlus22135298
358SAANPIIYNFLSGKFdbPTM 3.0;PhosphoSitePlus;curated18198212; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MEPSATPGAQ MGVPPGSREP SPVPPDYEDE FLRYLWRDYL YPKQYEWVLI AAYVAVFVVA 60
LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL PASLLVDITE SWLFGHALCK 120
VIPYLQAVSV SVAVLTLSFI ALDRWYAICH PLLFKSTARR ARGSILGIWA VSLAIMVPQA 180
AVMECSSVLP ELANRTRLFS VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR 240
KLWGRQIPGT TSALVRNWKR PSDQLGDLEQ GLSGEPQPRA RAFLAEVKQM RARRKTAKML 300
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN SAANPIIYNF 360
LSGKFREQFK AAFSCCLPGL GPCGSLKAPS PRSSASHKSL SLQSRCSISK ISEHVVLTSV 420
TTVLP 426
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
IPR000204--Orexin_rcpt
IPR004059--Orexin_rcpt_1
PROSITE

PS00237--G_PROTEIN_RECEP_F1_1
PS50262--G_PROTEIN_RECEP_F1_2
Pfam

PF00001--7tm_1
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0004930--F:G-protein coupled receptor activity
GO:0008188--F:neuropeptide receptor activity
GO:0016499--F:orexin receptor activity
GO:0042277--F:peptide binding
GO:0017046--F:peptide hormone binding
GO:0032870--P:cellular response to hormone stimulus
GO:0007631--P:feeding behavior
GO:0007218--P:neuropeptide signaling pathway
GO:0045187--P:regulation of circadian sleep/wake cycle, sleep
GO:1901652--P:response to peptide
GO:0007268--P:synaptic transmission