dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001592
Uniprot Accession O43610; SPY3_HUMAN; A8K0H8;
Genbank Protein ID NP_001291919.1; NP_005831.1; XP_011529400.1; XP_011529401.1; XP_011529402.1; XP_011529403.1;
Genbank Nucleotide ID NM_001304990.1; NM_005840.2; XM_011531098.1; XM_011531099.1; XM_011531100.1; XM_011531101.1;
Protein Name Protein sprouty homolog 3
Protein Synonyms/Alias
Gene Name SPRY3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
27STHASNDYVERPPAPdbPTM 3.0;PhosphoSitePlus;curated19534553; 16381945; 23193290; 22135298; 22817900
60WSLATMPTSLPRSLSPhosphoSitePlus22135298
274NTVCRKISSGSAPFPPhosphoSitePlus;curated22135298; 25627689; 23090842
275TVCRKISSGSAPFPKcurated22199227
277CRKISSGSAPFPKAQcurated23090842
Sequence
(Fasta)		MDAAVTDDFQ QILPIEQLRS THASNDYVER PPAPCKQALS SPSLIVQTHK SDWSLATMPT 60
SLPRSLSQCH QLQPLPQHLS QSSIASSMSH STTASDQRLL ASITPSPSGQ SIIRTQPGAG 120
VHPKADGALK GEAEQSAGHP SEHLFICEEC GRCKCVPCTA ARPLPSCWLC NQRCLCSAES 180
LLDYGTCLCC VKGLFYHCST DDEDNCADEP CSCGPSSCFV RWAAMSLISL FLPCLCCYLP 240
TRGCLHLCQQ GYDSLRRPGC RCKRHTNTVC RKISSGSAPF PKAQEKSV 289
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR007875--Sprouty
IPR030786--SPRY3
PROSITE

PS51227--SPR
Pfam

PF05210--Sprouty
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0061564--P:axon development
GO:0007275--P:multicellular organismal development
GO:0009966--P:regulation of signal transduction