dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001591
Uniprot Accession O43609; SPY1_HUMAN; D3DNX6; Q6PNE0;
Genbank Protein ID NP_001244967.1; NP_001244968.1; NP_005832.1; NP_955359.1; XP_005262743.1;
Genbank Nucleotide ID NM_001258038.1; NM_001258039.1; NM_005841.2; NM_199327.2; XM_005262686.1;
Protein Name Protein sprouty homolog 1
Protein Synonyms/Alias
Gene Name SPRY1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
9DPQNQHGSGSSLVVIcurated25850435
50QIKAIRGSNEYTEGPPhosphoSitePlus;curated22135298; 25850435; 23898821
53AIRGSNEYTEGPSVVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17389395; 18083107; 19534553; 16381945; 23193290; 17360941;
54IRGSNEYTEGPSVVKPhosphoSitePlus22135298
89PINVNNNYEHRHTSHdbPTM 3.0;PhosphoSitePlus;curated18180459; 20736484; 16381945; 23193290; 22135298; 22817900;
123STGSAASSGSNSSASPhosphoSitePlus22135298
125GSAASSGSNSSASSEcurated23898821
131GSNSSASSEQGLLGRPhosphoSitePlus22135298
139EQGLLGRSPPTRPVPcurated23898821
169IVDDLKGSLKEDLTQcurated23898821
304CKNSNTVYCKLESCPPhosphoSitePlus22135298
Sequence
(Fasta)		MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS NEYTEGPSVV 60
KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA VLPSNARGPI LSRSTSTGSA 120
ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI 180
CEQCGKCKCG ECTAPRTLPS CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS 240
YSDNPCSCSQ SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS 300
NTVYCKLESC PSRGQGKPS
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0472--Membrane
KW-1185--Reference proteome
Interpro

IPR007875--Sprouty
IPR030783--SPRY1
PROSITE

PS51227--SPR
Pfam

PF05210--Sprouty
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0060449--P:bud elongation involved in lung branching
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0000132--P:establishment of mitotic spindle orientation
GO:0001656--P:metanephros development
GO:0008285--P:negative regulation of cell proliferation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0040037--P:negative regulation of fibroblast growth factor receptor signaling pathway
GO:0034260--P:negative regulation of GTPase activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0051387--P:negative regulation of neurotrophin TRK receptor signaling pathway
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0001759--P:organ induction
GO:0001657--P:ureteric bud development