| Tag |
Content |
| dbPAF ID |
dbPAF-0001590 |
| Uniprot Accession |
O43603; GALR2_HUMAN; A5JUU4; Q32MN8;
|
| Genbank Protein ID |
NP_003848.1;
|
| Genbank Nucleotide ID |
NM_003857.3;
|
| Protein Name |
Galanin receptor type 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
GALR2 |
| Gene Synonyms/Alias |
GALNR2; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).Functional Description
Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MNVSGCPGAG NASQAGGGGG WHPEAVIVPL LFALIFLVGT VGNTLVLAVL LRGGQAVSTT 60
NLFILNLGVA DLCFILCCVP FQATIYTLDG WVFGSLLCKA VHFLIFLTMH ASSFTLAAVS 120
LDRYLAIRYP LHSRELRTPR NALAAIGLIW GLSLLFSGPY LSYYRQSQLA NLTVCHPAWS 180
APRRRAMDIC TFVFSYLLPV LVLGLTYART LRYLWRAVDP VAAGSGARRA KRKVTRMILI 240
VAALFCLCWM PHHALILCVW FGQFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR 300
KGFRTICAGL LGRAPGRASG RVCAAARGTH SGSVLERESS DLLHMSEAAG ALRPCPGASQ 360
PCILEPCPGP SWQGPKAGDS ILTVDVA
388Fasta Sequence
>O43603|GALR2|Homo sapiens(Human)
MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
|
| Keyword |
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0675--Receptor
KW-1185--Reference proteome
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR003907--GAL2_rcpt
IPR000405--Galanin_rcpt
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
|
| PROSITE |
PS00237--G_PROTEIN_RECEP_F1_1
PS50262--G_PROTEIN_RECEP_F1_2
|
| Pfam |
PF00001--7tm_1
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0004966--F:galanin receptor activity
GO:0017046--F:peptide hormone binding
GO:0007188--P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007166--P:cell surface receptor signaling pathway
GO:0007586--P:digestion
GO:0007631--P:feeding behavior
GO:0007611--P:learning or memory
GO:0007275--P:multicellular organismal development
GO:0006936--P:muscle contraction
GO:0007194--P:negative regulation of adenylate cyclase activity
GO:0031175--P:neuron projection development
GO:0007218--P:neuropeptide signaling pathway
GO:0007200--P:phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:1902608--P:positive regulation of large conductance calcium-activated potassium channel activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007268--P:synaptic transmission
|
