dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001589
Uniprot Accession O43602; DCX_HUMAN; A6NFY6; A9Z1V8; D3DUY8; D3DUY9; D3DUZ0; O43911; Q5JYZ5;
Genbank Protein ID NP_000546.2; NP_835364.1; NP_835365.1; NP_835366.1;
Genbank Nucleotide ID NM_000555.3; NM_178151.2; NM_178152.2; NM_178153.2;
Protein Name Neuronal migration protein doublecortin
Protein Synonyms/Alias Doublin;Lissencephalin-X;Lis-X;
Gene Name DCX
Gene Synonyms/Alias DBCN;LISX;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
Phosphorylation Sites
 dbPAF PTMs: 25 (View all)
PositionPeptidesSourceReferences ( PMIDs )
28EMLTLGSSFCSLQGEdbPTM 3.014741103; 16381945; 23193290
109SRMNGLPSPTHSAHCdbPTM 3.0;HPRD 9;PhosphoSitePlus14741103; 16381945; 23193290; 18988627; 22135298
111MNGLPSPTHSAHCSFPhosphoSitePlus22135298
128TRTLQALSNEKKAKKdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus15632197; 16381945; 23193290; 22135298
151RYFKGIVYAVSSDRFdbPTM 3.0;Phospho.ELM 9.014757045; 16381945; 23193290
155GIVYAVSSDRFRSFDPhosphoSitePlus22135298
171LLADLTRSLSDNINLPhosphoPep 2.019060867
184NLPQGVRYIYTIDGSPhosphoSitePlus22135298
186PQGVRYIYTIDGSRKPhosphoSitePlus22135298
284RVLLNKKTAHSFEQVPhosphoSitePlus22135298
287LNKKTAHSFEQVLTDdbPTM 3.0;PhosphoSitePlus14741103; 16381945; 23193290; 22135298
303TEAIKLETGVVKKLYPhosphoSitePlus22135298
346RYAQDDFSLDENECRPhosphoPep 2.019060867
368ATAGPKASPTPQKTSdbPTM 3.0;HPRD 9;PhosphoSitePlus14741103; 16381945; 23193290; 18988627; 22135298
370AGPKASPTPQKTSAKdbPTM 3.0;HPRD 914741103; 16381945; 23193290; 18988627
378PQKTSAKSPGPMRRSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus15632197; 16381945; 23193290; 14741103; 18988627; 22135298
387GPMRRSKSPADSANGdbPTM 3.0;HPRD 9;PhosphoSitePlus14741103; 15345747; 16381945; 23193290; 18988627; 22135298
396ADSANGTSSSQLSTPdbPTM 3.0;HPRD 9;PhosphoSitePlus15345747; 16381945; 23193290; 18988627; 22135298
401GTSSSQLSTPKSKQSPhosphoSitePlus22135298
402TSSSQLSTPKSKQSPdbPTM 3.0;HPRD 9;PhosphoSitePlus14741103; 16381945; 23193290; 18988627; 22135298
Sequence
(Fasta)		MKTLPLHSHC TEMQRLLPKL EMLTLGSSFC SLQGEFCQAM DSFTTVSHVG MCEETDASFN 60
VFSPKFQFDR SHCQSLRFHQ NMELDFGHFD ERDKTSRNMR GSRMNGLPSP THSAHCSFYR 120
TRTLQALSNE KKAKKVRFYR NGDRYFKGIV YAVSSDRFRS FDALLADLTR SLSDNINLPQ 180
GVRYIYTIDG SRKIGSMDEL EEGESYVCSS DNFFKKVEYT KNVNPNWSVN VKTSANMKAP 240
QSLASSNSAQ ARENKDFVRP KLVTIIRSGV KPRKAVRVLL NKKTAHSFEQ VLTDITEAIK 300
LETGVVKKLY TLDGKQVTCL HDFFGDDDVF IACGPEKFRY AQDDFSLDEN ECRVMKGNPS 360
ATAGPKASPT PQKTSAKSPG PMRRSKSPAD SANGTSSSQL STPKSKQSPI STPTSPGSLR 420
KHKDLYLPLS LDDSDSLGDS M 442
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0887--Epilepsy
KW-0451--Lissencephaly
KW-0493--Microtubule
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR020636--Ca/CaM-dep_Ca-dep_prot_Kinase
IPR017302--Doublecortin_chordata
IPR003533--Doublecortin_dom
PROSITE

PS50309--DC
Pfam

PF03607--DCX
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0043005--C:neuron projection
GO:0009931--F:calcium-dependent protein serine/threonine kinase activity
GO:0005516--F:calmodulin binding
GO:0004683--F:calmodulin-dependent protein kinase activity
GO:0008017--F:microtubule binding
GO:0019901--F:protein kinase binding
GO:0048675--P:axon extension
GO:0007411--P:axon guidance
GO:0007420--P:brain development
GO:0007417--P:central nervous system development
GO:0021952--P:central nervous system projection neuron axonogenesis
GO:0048813--P:dendrite morphogenesis
GO:0035556--P:intracellular signal transduction
GO:0007399--P:nervous system development
GO:0001764--P:neuron migration
GO:0018105--P:peptidyl-serine phosphorylation
GO:0046777--P:protein autophosphorylation
GO:0051602--P:response to electrical stimulus