dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001588
Uniprot Accession O43598; DNPH1_HUMAN; B2LUJ9;
Genbank Protein ID NP_006434.1; NP_954653.1;
Genbank Nucleotide ID NM_006443.2; NM_199184.1;
Protein Name 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Protein Synonyms/Alias c-Myc-responsive protein RCL;
Gene Name DNPH1
Gene Synonyms/Alias C6orf108;RCL;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
10AAMVPGRSESWERGEdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298; 23186163; 26074081
12MVPGRSESWERGEPGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 20068231; 20363803; 22115753;
28PALYFCGSIRGGREDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 20068231; 18988627; 21081558;
95DVVVAEVTQPSLGVGPhosphoSitePlus22135298
98VAEVTQPSLGVGYELPhosphoSitePlus;UniProt22135298; 24275569
123LCLFRPQSGRVLSAMPhosphoSitePlus;curated22135298; 23917254
128PQSGRVLSAMIRGAAdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated20166139; 16381945; 23193290; 18988627; 22135298; 24275569;
138IRGAADGSRFQVWDYPhosphoSitePlus;UniProt22135298; 24275569
169PPGQVAASPDPTT--dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 17287340; 18669648; 19413330; 19690332; 16381945;
173VAASPDPTT------dbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated21659604; 16381945; 23193290; 21081558; 19060867; 22135298;
174AASPDPTT-------dbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated21659604; 16381945; 23193290; 21081558; 19060867; 22135298;
Sequence
(Fasta)		MAAAMVPGRS ESWERGEPGR PALYFCGSIR GGREDRTLYE RIVSRLRRFG TVLTEHVAAA 60
ELGARGEEAA GGDRLIHEQD LEWLQQADVV VAEVTQPSLG VGYELGRAVA FNKRILCLFR 120
PQSGRVLSAM IRGAADGSRF QVWDYEEGEV EALLDRYFEA DPPGQVAASP DPTT 175
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0326--Glycosidase
KW-0378--Hydrolase
KW-0546--Nucleotide metabolism
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR028607--DNPH1
IPR007710--Nucleoside_deoxyribTrfase
PROSITE
Pfam

PF05014--Nuc_deoxyrib_tr
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0070694--F:deoxyribonucleoside 5'-monophosphate N-glycosidase activity
GO:0050144--F:nucleoside deoxyribosyltransferase activity
GO:0008283--P:cell proliferation
GO:0009159--P:deoxyribonucleoside monophosphate catabolic process
GO:0030855--P:epithelial cell differentiation
GO:0009116--P:nucleoside metabolic process
GO:0009117--P:nucleotide metabolic process
GO:0030307--P:positive regulation of cell growth