dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001587
Uniprot Accession O43597; SPY2_HUMAN; B2R9J9; Q5T6Z7;
Genbank Protein ID NP_005833.1; XP_005266274.1; XP_006719816.1; XP_011533169.1;
Genbank Nucleotide ID NM_005842.2; XM_005266217.1; XM_006719753.1; XM_011534867.1;
Protein Name Protein sprouty homolog 2
Protein Synonyms/Alias
Gene Name SPRY2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
Phosphorylation Sites
 dbPAF PTMs: 34 (View all)
PositionPeptidesSourceReferences ( PMIDs )
7-MEARAQSGNGSQPLdbPTM 3.0;PhosphoSitePlus;curated18683950; 19690147; 16381945; 23193290; 22135298; 22817900
11RAQSGNGSQPLLQTPdbPTM 3.0;PhosphoSitePlus;curated18683950; 16381945; 23193290; 22135298; 22817900
17GSQPLLQTPRDGGRQdbPTM 3.0;PhosphoSitePlus;curated18683950; 16381945; 23193290; 22135298; 25850435; 22817900
42TQQVHVLSLDQIRAIdbPTM 3.0;PhosphoSitePlus;curated18683950; 19690147; 16381945; 23193290; 22135298; 22817900
55AIRNTNEYTEGPTVVdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;PhosphoSitePlus;curated12815057; 12593795; 16000370; 15637081; 15564375; 16381945;
56IRNTNEYTEGPTVVPdbPTM 3.0;PhosphoSitePlus;curated18683950; 16381945; 23193290; 22135298; 22817900
75KPAPRPSTQHKHERLdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated18678649; 16381945; 23193290; 20804972; 22135298; 22817900
110ARAPLSRSISTVSSGcurated24961811
112APLSRSISTVSSGSRdbPTM 3.0;PhosphoSitePlus;curated16479008; 17255109; 19690147; 19864419; 16381945; 23193290;
115SRSISTVSSGSRSSTdbPTM 3.0;PhosphoSitePlus;curated17255109; 18683950; 16381945; 23193290; 22135298; 22817900
116RSISTVSSGSRSSTRdbPTM 3.0;PhosphoSitePlus;curated18683950; 16381945; 23193290; 22135298; 22817900
118ISTVSSGSRSSTRTSdbPTM 3.0;PhosphoSitePlus;curated18683950; 16381945; 23193290; 22135298; 22817900
121VSSGSRSSTRTSTSSdbPTM 3.0;PhosphoSitePlus;curated16479008; 19690147; 19864419; 16381945; 23193290; 22135298;
124GSRSSTRTSTSSSSSPhosphoSitePlus22135298
128STRTSTSSSSSEQRLPhosphoSitePlus22135298
131TSTSSSSSEQRLLGSPhosphoSitePlus22135298
138SEQRLLGSSFSSGPVdbPTM 3.0;PhosphoSitePlus;curated17255109; 18683950; 16381945; 23193290; 22135298; 25850435;
139EQRLLGSSFSSGPVAdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18578522; 18683950; 20815410; 16381945; 23193290; 18988627;
141RLLGSSFSSGPVADGdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 18683950; 19690147; 22135298;
142LLGSSFSSGPVADGIdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 18683950; 22135298; 25003641;
Sequence
(Fasta)		MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT 60
VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQHSQVH SSARAPLSRS ISTVSSGSRS 120
STRTSTSSSS SEQRLLGSSF SSGPVADGII RVQPKSELKP GELKPLSKED LGLHAYRCED 180
CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN 240
PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 300
CKVPTVPPRN FEKPT 316
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0472--Membrane
KW-0493--Microtubule
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR007875--Sprouty
IPR030780--SPRY2
PROSITE

PS51227--SPR
Pfam

PF05210--Sprouty
Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0032587--C:ruffle membrane
GO:0019901--F:protein kinase binding
GO:0043539--F:protein serine/threonine kinase activator activity
GO:0030291--F:protein serine/threonine kinase inhibitor activity
GO:0060449--P:bud elongation involved in lung branching
GO:0045165--P:cell fate commitment
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0000132--P:establishment of mitotic spindle orientation
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0042472--P:inner ear morphogenesis
GO:0060437--P:lung growth
GO:0043066--P:negative regulation of apoptotic process
GO:0031345--P:negative regulation of cell projection organization
GO:0008285--P:negative regulation of cell proliferation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0040037--P:negative regulation of fibroblast growth factor receptor signaling pathway
GO:0034260--P:negative regulation of GTPase activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0051387--P:negative regulation of neurotrophin TRK receptor signaling pathway
GO:0010801--P:negative regulation of peptidyl-threonine phosphorylation
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0010628--P:positive regulation of gene expression
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0045595--P:regulation of cell differentiation
GO:0007605--P:sensory perception of sound