dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001584
Uniprot Accession O43586; PPIP1_HUMAN; B5BU74; B5BUK4; O43585; O95657;
Genbank Protein ID NP_003969.2;
Genbank Nucleotide ID NM_003978.3;
Protein Name Proline-serine-threonine phosphatase-interacting protein 1
Protein Synonyms/Alias
Gene Name PSTPIP1
Gene Synonyms/Alias CD2BP1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
119QKEQRKKYEAVMDRVdbPTM 3.0;PhosphoSitePlus18083107; 16381945; 23193290; 22135298
140LYKKAMESKKTYEQKPhosphoSitePlus22135298
173HQKQVEKSQNKARQCPhosphoSitePlus22135298
211EWEQEHRTTCEAFQLPhosphoSitePlus;curated22135298; 25627689
212WEQEHRTTCEAFQLQPhosphoSitePlus;curated22135298; 25627689
260RLTLEGCSIDADIDSPhosphoSitePlus22135298
312CGMIKRFSGLLHGSPPhosphoSitePlus22135298
318FSGLLHGSPKTTSLAPhosphoSitePlus;curated22135298; 23911959; 25003641; 20873877
333ASAASTETLTPTPERPhosphoSitePlus22135298
345PERNEGVYTAIAVQEdbPTM 3.0;Phospho.ELM 9.0;HPRD 911163214; 16381945; 23193290; 18988627
Sequence
(Fasta)		MMPQLQFKDA FWCRDFTAHT GYEVLLQRLL DGRKMCKDME ELLRQRAQAE ERYGKELVQI 60
ARKAGGQTEI NSLRASFDSL KQQMENVGSS HIQLALTLRE ELRSLEEFRE RQKEQRKKYE 120
AVMDRVQKSK LSLYKKAMES KKTYEQKCRD ADDAEQAFER ISANGHQKQV EKSQNKARQC 180
KDSATEAERV YRQSIAQLEK VRAEWEQEHR TTCEAFQLQE FDRLTILRNA LWVHSNQLSM 240
QCVKDDELYE EVRLTLEGCS IDADIDSFIQ AKSTGTEPPA PVPYQNYYDR EVTPLTSSPG 300
IQPSCGMIKR FSGLLHGSPK TTSLAASAAS TETLTPTPER NEGVYTAIAV QEIQGNPASP 360
AQEYRALYDY TAQNPDELDL SAGDILEVIL EGEDGWWTVE RNGQRGFVPG SYLEKL 417
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0254--Endocytosis
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0399--Innate immunity
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR030777--PSTPIP1
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF14604--SH3_9
Gene Ontology

GO:0032154--C:cleavage furrow
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0016020--C:membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0001931--C:uropod
GO:0007155--P:cell adhesion
GO:0016477--P:cell migration
GO:0006897--P:endocytosis
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0035872--P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0007165--P:signal transduction