dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001583
Uniprot Accession O43583; DENR_HUMAN; Q9H3U6; Q9UKZ0;
Genbank Protein ID NP_003668.2;
Genbank Nucleotide ID NM_003677.4;
Protein Name Density-regulated protein
Protein Synonyms/Alias
Gene Name DENR
Gene Synonyms/Alias DRP1;H14;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
6--MAADISESSGADCPhosphoSitePlus;curated22135298; 25627689; 22199227
8MAADISESSGADCKGcurated25627689; 22199227
9AADISESSGADCKGDPhosphoSitePlus;curated22135298; 25627689; 22199227
20CKGDPRNSAKLDADYdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
27SAKLDADYPLRVLYCdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298
69PNEFAKLTVENSPKQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17287340; 19413330; 16381945; 23193290; 18669648; 19690332;
73AKLTVENSPKQEAGIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17287340; 18669648; 19413330; 19690332; 16381945; 23193290;
81PKQEAGISEGQGTAGPhosphoSitePlus;curated22135298; 25627689
86GISEGQGTAGEEEEKdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated19413330; 16381945; 23193290; 19362540; 18988627; 19060867;
189WPEVDDDSIEDLGEVPhosphoSitePlus22135298
Sequence
(Fasta)		MAADISESSG ADCKGDPRNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV AKCRQWLEKN 60
FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG RGQIKQKKKT VPQKVTIAKI 120
PRAKKKYVTR VCGLATFEID LKEAQRFFAQ KFSCGASVTG EDEIIIQGDF TDDIIDVIQE 180
KWPEVDDDSI EDLGEVKK 199
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
Interpro

IPR005873--Drp1
IPR001950--TIF_SUI1
PROSITE

PS50296--SUI1
Pfam

PF01253--SUI1
Gene Ontology

GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0002192--P:IRES-dependent translational initiation
GO:0032790--P:ribosome disassembly