dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001582
Uniprot Accession O43581; SYT7_HUMAN; F5GZU9; Q08AH6;
Genbank Protein ID NP_001238994.1; NP_001287702.1; NP_004191.2;
Genbank Nucleotide ID NM_001252065.1; NM_001300773.1; NM_004200.3;
Protein Name Synaptotagmin-7
Protein Synonyms/Alias IPCA-7;Prostate cancer-associated protein 7;Synaptotagmin VII;SytVII;
Gene Name SYT7
Gene Synonyms/Alias PCANAP7;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
52LGKRYKNSLETVGTPPhosphoSitePlus;curated22135298; 23898821; 25849741; 24961811
55RYKNSLETVGTPDSGcurated25849741
58NSLETVGTPDSGRGRdbPTM 3.0;PhosphoSitePlus;curated20886841; 16381945; 23193290; 22135298; 23898821; 24961811
61ETVGTPDSGRGRSEKPhosphoSitePlus;curated22135298; 24961811
305IGGTSDPYVKVWLMYPhosphoSitePlus22135298
312YVKVWLMYKDKRVEKPhosphoSitePlus22135298
322KRVEKKKTVTMKRNLdbPTM 3.0;PhosphoSitePlus;curated18187866; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK NSLETVGTPD 60
SGRGRSEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTEP RSSVSDLVNS LTSEMLMLSP 120
GSEEDEAHEG CSRENLGRIQ FSVGYNFQES TLTVKIMKAQ ELPAKDFSGT SDPFVKIYLL 180
PDKKHKLETK VKRKNLNPHW NETFLFEGFP YEKVVQRILY LQVLDYDRFS RNDPIGEVSI 240
PLNKVDLTQM QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG 300
TSDPYVKVWL MYKDKRVEKK KTVTMKRNLN PIFNESFAFD IPTEKLRETT IIITVMDKDK 360
LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ LKA 404
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR000008--C2_dom
IPR001565--Synaptotagmin
IPR015427--Synaptotagmin7
PROSITE

PS50004--C2
Pfam

PF00168--C2
Gene Ontology

GO:0030054--C:cell junction
GO:0031045--C:dense core granule
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0005764--C:lysosome
GO:0005886--C:plasma membrane
GO:0030672--C:synaptic vesicle membrane
GO:0043195--C:terminal bouton
GO:0005509--F:calcium ion binding
GO:0005544--F:calcium-dependent phospholipid binding
GO:0030276--F:clathrin binding
GO:0019905--F:syntaxin binding
GO:0048791--P:calcium ion-dependent exocytosis of neurotransmitter
GO:0001778--P:plasma membrane repair
GO:0045956--P:positive regulation of calcium ion-dependent exocytosis
GO:0017158--P:regulation of calcium ion-dependent exocytosis
GO:0050796--P:regulation of insulin secretion
GO:0016079--P:synaptic vesicle exocytosis