dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001580
Uniprot Accession O43570; CAH12_HUMAN; B2RE24; Q53YE5; Q9BWG2;
Genbank Protein ID NP_001209.1; NP_996808.1;
Genbank Nucleotide ID NM_001218.4; NM_206925.2;
Protein Name Carbonic anhydrase 12
Protein Synonyms/Alias Carbonate dehydratase XII;Carbonic anhydrase XII;CA-XII;Tumor antigen HOM-RCC-3.1.3;
Gene Name CA12
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Reversible hydration of carbon dioxide.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
342GDNKGVIYKPATKMEdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC GGLLQSPIDL 60
HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL PSDMHIQGLQ SRYSATQLHL 120
HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN 180
PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR 240
NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QVQVCTAAGL 300
SLGIILSLAL AGILGICIVV VVSIWLFRRK SIKKGDNKGV IYKPATKMET EAHA 355
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0456--Lyase
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
Interpro

IPR001148--Carbonic_anhydrase_a
IPR023561--Carbonic_anhydrase_a-class
IPR018338--Carbonic_anhydrase_a-class_CS
IPR018430--Carbonic_anhydrase_CA12
PROSITE

PS00162--ALPHA_CA_1
PS51144--ALPHA_CA_2
Pfam

PF00194--Carb_anhydrase
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0004089--F:carbonate dehydratase activity
GO:0008270--F:zinc ion binding
GO:0015701--P:bicarbonate transport
GO:0055064--P:chloride ion homeostasis
GO:0006730--P:one-carbon metabolic process
GO:0044281--P:small molecule metabolic process