dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001577
Uniprot Accession O43561; LAT_HUMAN; B7WPI0; C7C5T6; G5E9K3; O43919;
Genbank Protein ID NP_001014987.1; NP_001014988.1; NP_001014989.2; NP_055202.1;
Genbank Nucleotide ID NM_001014987.1; NM_001014988.1; NM_001014989.1; NM_014387.3;
Protein Name Linker for activation of T-cells family member 1
Protein Synonyms/Alias 36 kDa phospho-tyrosine adapter protein;pp36;p36-38;
Gene Name LAT
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Phosphorylation Sites
dbPAF PTMs: 33 (View all)
PositionPeptidesSourceReferences ( PMIDs )
35HCHRLPGSYDSTSSDdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 19060867; 22135298
36CHRLPGSYDSTSSDSPhosphoSitePlus22135298
38RLPGSYDSTSSDSLYdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated15659558; 16381945; 23193290; 22135298; 19690332
39LPGSYDSTSSDSLYPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18088087; 19690332; 16381945; 23193290; 15659558; 18988627;
40PGSYDSTSSDSLYPRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 15659558; 15144186; 18988627;
41GSYDSTSSDSLYPRGdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 19060867; 22135298; 26074081
43YDSTSSDSLYPRGIQdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 19060867; 22135298
45STSSDSLYPRGIQFKdbPTM 3.0;PhosphoSitePlus19605366; 16381945; 23193290; 22135298
68PPAYPPVTSYPPLSQPhosphoSitePlus22135298
70AYPPVTSYPPLSQPDPhosphoSitePlus22135298
74VTSYPPLSQPDLLPIPhosphoSitePlus22135298
84DLLPIPRSPQPLGGSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18088087; 16381945; 23193290; 15659558; 18988627; 22135298;
91SPQPLGGSHRTPSSRPhosphoSitePlus;curated22135298; 26074081
94PLGGSHRTPSSRRDSPhosphoSitePlus22135298
96GGSHRTPSSRRDSDGPhosphoSitePlus;curated22135298; 26074081
97GSHRTPSSRRDSDGAPhosphoSitePlus;curated22135298; 26074081
101TPSSRRDSDGANSVAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18088087; 19690332; 16381945; 23193290; 18988627; 22135298;
106RDSDGANSVASYENEdbPTM 3.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 22135298; 26074081
109DGANSVASYENEGASdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18088087; 16381945; 23193290; 19690332; 18988627; 22135298;
110GANSVASYENEGASGPhosphoSitePlus;curated22135298; 19690332
Sequence
(Fasta)
MEEAILVPCV LGLLLLPILA MLMALCVHCH RLPGSYDSTS SDSLYPRGIQ FKRPHTVAPW 60
PPAYPPVTSY PPLSQPDLLP IPRSPQPLGG SHRTPSSRRD SDGANSVASY ENEGASGIRG 120
AQAGWGVWGP SWTRLTPVSL PPEPACEDAD EDEDDYHNPG YLVVLPDSTP ATSTAAPSAP 180
ALSTPGIRDS AFSMESIDDY VNVPESGESA EASLDGSREY VNVSQELHPG AAKTEPAALS 240
SQEAEEVEEE GAPDYENLQE LN 263
Keyword

KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0391--Immunity
KW-0449--Lipoprotein
KW-0467--Mast cell degranulation
KW-0472--Membrane
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0735--Signal-anchor
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR008359--Linker_for_activat_Tcells_prot

PROSITE
Pfam

PF15234--LAT

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0001772--C:immunological synapse
GO:0016021--C:integral component of membrane
GO:0042629--C:mast cell granule
GO:0045121--C:membrane raft
GO:0005886--C:plasma membrane
GO:0019901--F:protein kinase binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0000186--P:activation of MAPKK activity
GO:0002250--P:adaptive immune response
GO:0007411--P:axon guidance
GO:0007596--P:blood coagulation
GO:0019722--P:calcium-mediated signaling
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0010467--P:gene expression
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0002260--P:lymphocyte homeostasis
GO:0000165--P:MAPK cascade
GO:0043303--P:mast cell degranulation
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0030168--P:platelet activation
GO:0045860--P:positive regulation of protein kinase activity
GO:0007265--P:Ras protein signal transduction
GO:0050863--P:regulation of T cell activation
GO:0007264--P:small GTPase mediated signal transduction
GO:0042110--P:T cell activation
GO:0050852--P:T cell receptor signaling pathway
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway