dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001576
Uniprot Accession O43559; FRS3_HUMAN; Q5T3D5;
Genbank Protein ID NP_006644.1; XP_011512556.1; XP_011512557.1;
Genbank Nucleotide ID NM_006653.4; XM_011514254.1; XM_011514255.1;
Protein Name Fibroblast growth factor receptor substrate 3
Protein Synonyms/Alias
Gene Name FRS3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
73GYDSNLFSFESGRRCPhosphoSitePlus22135298
76SNLFSFESGRRCQTGPhosphoSitePlus22135298
166SAPRRLSTSSLRHPSPhosphoSitePlus22135298
167APRRLSTSSLRHPSLPhosphoSitePlus22135298
349EAGDDGDSRDGLTPSPhosphoSitePlus22135298
417EPPRQLNYIQVELKGdbPTM 3.0;HPRD 911432792; 16381945; 23193290; 18988627
455PARSSDSYAVIDLKKdbPTM 3.0;HPRD 9;PhosphoSitePlus11432792; 16381945; 23193290; 18988627; 22135298
Sequence
(Fasta)		MGSCCSCLNR DSVPDNHPTK FKVTNVDDEG VELGSGVMEL TQSELVLHLH RREAVRWPYL 60
CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEEIFNL LQDLMQCNSI NVMEEPVIIT 120
RNSHPAELDL PRAPQPPNAL GYTVSSFSNG CPGEGPRFSA PRRLSTSSLR HPSLGEESTH 180
ALIAPDEQSH TYVNTPASED DHRRGRHCLQ PLPEGQAPFL PQARGPDQRD PQVFLQPGQV 240
KFVLGPTPAR RHMVKCQGLC PSLHDPPHHN NNNEAPSECP AQPKCTYENV TGGLWRGAGW 300
RLSPEEPGWN GLAHRRAALL HYENLPPLPP VWESQAQQLG GEAGDDGDSR DGLTPSSNGF 360
PDGEEDETPL QKPTSTRAAI RSHGSFPVPL TRRRGSPRVF NFDFRRPGPE PPRQLNYIQV 420
ELKGWGGDRP KGPQNPSSPQ APMPTTHPAR SSDSYAVIDL KKTVAMSNLQ RALPRDDGTA 480
RKTRHNSTDL PL 493
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR002404--IRS_PTB
IPR011993--PH/PTB_dom
PROSITE

PS51064--IRS_PTB
Pfam

PF02174--IRS
Gene Ontology

GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0005104--F:fibroblast growth factor receptor binding
GO:0042802--F:identical protein binding
GO:0000186--P:activation of MAPKK activity
GO:0007411--P:axon guidance
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0007265--P:Ras protein signal transduction
GO:0007165--P:signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway