| Tag |
Content |
| dbPAF ID |
dbPAF-0001575 |
| Uniprot Accession |
O43557; TNF14_HUMAN; A8K7M2; C9J5H4; O75476; Q6FHA1; Q8WVF8; Q96LD2;
|
| Genbank Protein ID |
NP_003798.2; NP_742011.2; XP_005259727.1;
|
| Genbank Nucleotide ID |
NM_003807.3; NM_172014.2; XM_005259670.2;
|
| Protein Name |
Tumor necrosis factor ligand superfamily member 14 |
| Protein Synonyms/Alias |
Herpes virus entry mediator ligand;HVEM-L;Herpesvirus entry mediator ligand; |
| Gene Name |
TNFSF14 |
| Gene Synonyms/Alias |
HVEML;LIGHT;UNQ391/PRO726; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.Functional Description
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MEESVVRPSV FVVDGQTDIP FTRLGRSHRR QSCSVARVGL GLLLLLMGAG LAVQGWFLLQ 60
LHWRLGEMVT RLPDGPAGSW EQLIQERRSH EVNPAAHLTG ANSSLTGSGG PLLWETQLGL 120
AFLRGLSYHD GALVVTKAGY YYIYSKVQLG GVGCPLGLAS TITHGLYKRT PRYPEELELL 180
VSQQSPCGRA TSSSRVWWDS SFLGGVVHLE AGEKVVVRVL DERLVRLRDG TRSYFGAFMV 240
241Fasta Sequence
>O43557|TNFSF14|Homo sapiens(Human)
MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0202--Cytokine
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0735--Signal-anchor
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR006053--TNF
IPR006052--TNF_dom
IPR008983--Tumour_necrosis_fac-like_dom
|
| PROSITE |
PS50049--TNF_2
|
| Pfam |
PF00229--TNF
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005615--C:extracellular space
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0043027--F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0005102--F:receptor binding
GO:0006915--P:apoptotic process
GO:0071260--P:cellular response to mechanical stimulus
GO:0006955--P:immune response
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045663--P:positive regulation of myoblast differentiation
GO:1901741--P:positive regulation of myoblast fusion
GO:0010820--P:positive regulation of T cell chemotaxis
GO:0008588--P:release of cytoplasmic sequestered NF-kappaB
GO:0007165--P:signal transduction
GO:0042110--P:T cell activation
GO:0031295--P:T cell costimulation
GO:0043029--P:T cell homeostasis
GO:0042098--P:T cell proliferation
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
|
