| Tag |
Content |
| dbPAF ID |
dbPAF-0001572 |
| Uniprot Accession |
O43548; TGM5_HUMAN; O43549; Q0VF40; Q9UEZ4;
|
| Genbank Protein ID |
NP_004236.1; NP_963925.2;
|
| Genbank Nucleotide ID |
NM_004245.3; NM_201631.3;
|
| Protein Name |
Protein-glutamine gamma-glutamyltransferase 5 |
| Protein Synonyms/Alias |
Transglutaminase X;TG(X);TGX;TGase X;Transglutaminase-5;TGase-5; |
| Gene Name |
TGM5 |
| Gene Synonyms/Alias |
TGMX; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.Functional Description
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes. |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MAQGLEVALT DLQSSRNNVR HHTEEITVDH LLVRRGQAFN LTLYFRNRSF QPGLDNIIFV 60
VETGPLPDLA LGTRAVFSLA RHHSPSPWIA WLETNGATST EVSLCAPPTA AVGRYLLKIH 120
IDSFQGSVTA YQLGEFILLF NPWCPEDAVY LDSEPQRQEY VMNDYGFIYQ GSKNWIRPCP 180
WNYGQFEDKI IDICLKLLDK SLHFQTDPAT DCALRGSPVY VSRVVCAMIN SNDDNGVLNG 240
NWSENYTDGA NPAEWTGSVA ILKQWNATGC QPVRYGQCWV FAAVMCTVMR CLGIPTRVIT 300
NFDSGHDTDG NLIIDEYYDN TGRILGNKKK DTIWNFHVWN ECWMARKDLP PAYGGWQVLD 360
ATPQEMSNGV YCCGPASVRA IKEGEVDLNY DTPFVFSMVN ADCMSWLVQG GKEQKLHQDT 420
SSVGNFISTK SIQSDERDDI TENYKYEEGS LQERQVFLKA LQKLKARSFH GSQRGAELQP 480
SRPTSLSQDS PRSLHTPSLR PSDVVQVSLK FKLLDPPNMG QDICFVLLAL NMSSQFKDLK 540
VNLSAQSLLH DGSPLSPFWQ DTAFITLSPK EAKTYPCKIS YSQYSQYLST DKLIRISALG 600
EEKSSPEKIL VNKIITLSYP SITINVLGAA VVNQPLSIQV IFSNPLSEQV EDCVLTVEGS 660
GLFKKQQKVF LGVLKPQHQA SIILETVPFK SGQRQIQANM RSNKFKDIKG YRNVYVDFAL 720
721Fasta Sequence
>O43548|TGM5|Homo sapiens(Human)
MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL
|
| Keyword |
KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
|
| Interpro |
IPR023608--Gln_gamma-glutamylTfrase_euk
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR002931--Transglutaminase-like
IPR008958--Transglutaminase_C
IPR013808--Transglutaminase_CS
IPR001102--Transglutaminase_N
|
| PROSITE |
PS00547--TRANSGLUTAMINASES
|
| Pfam |
PF00927--Transglut_C
PF01841--Transglut_core
PF00868--Transglut_N
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0046872--F:metal ion binding
GO:0003810--F:protein-glutamine gamma-glutamyltransferase activity
GO:0006464--P:cellular protein modification process
GO:0008544--P:epidermis development
GO:0018149--P:peptide cross-linking
|
