dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001571
Uniprot Accession O43543; XRCC2_HUMAN; B2R925;
Genbank Protein ID NP_005422.1;
Genbank Nucleotide ID NM_005431.1;
Protein Name DNA repair protein XRCC2
Protein Synonyms/Alias X-ray repair cross-complementing protein 2;
Gene Name XRCC2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
10SAFHRAESGTELLARPhosphoSitePlus;curated22135298; 23917254; 23186163
12FHRAESGTELLARLEPhosphoSitePlus22135298
22LARLEGRSSLKEIEPcurated23898821
59TGKTEMLYHLTARCIPhosphoSitePlus22135298
247FFSKQDDSQSSNQFSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated17525332; 16381945; 23193290; 18988627; 22135298; 22817900
249SKQDDSQSSNQFSLVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated17525332; 16381945; 23193290; 18988627; 22135298; 22817900
Sequence
(Fasta)		MCSAFHRAES GTELLARLEG RSSLKEIEPN LFADEDSPVH GDILEFHGPE GTGKTEMLYH 60
LTARCILPKS EGGLEVEVLF IDTDYHFDML RLVTILEHRL SQSSEEIIKY CLGRFFLVYC 120
SSSTHLLLTL YSLESMFCSH PSLCLLILDS LSAFYWIDRV NGGESVNLQE STLRKCSQCL 180
EKLVNDYRLV LFATTQTIMQ KASSSSEEPS HASRRLCDVD IDYRPYLCKA WQQLVKHRMF 240
FSKQDDSQSS NQFSLVSRCL KSNSLKKHFF IIGESGVEFC 281
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR013632--DNA_recomb/repair_Rad51_C
IPR027417--P-loop_NTPase
IPR020588--RecA_ATP-bd
IPR030547--XRCC2
PROSITE

PS50162--RECA_2
Pfam

PF08423--Rad51
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0033063--C:Rad51B-Rad51C-Rad51D-XRCC2 complex
GO:0005657--C:replication fork
GO:0005524--F:ATP binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0003690--F:double-stranded DNA binding
GO:0000150--F:recombinase activity
GO:0003697--F:single-stranded DNA binding
GO:0051297--P:centrosome organization
GO:0006281--P:DNA repair
GO:0006302--P:double-strand break repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0045003--P:double-strand break repair via synthesis-dependent strand annealing
GO:0001701--P:in utero embryonic development
GO:0000707--P:meiotic DNA recombinase assembly
GO:0007126--P:meiotic nuclear division
GO:0000278--P:mitotic cell cycle
GO:0006312--P:mitotic recombination
GO:0035264--P:multicellular organism growth
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0050769--P:positive regulation of neurogenesis
GO:0007131--P:reciprocal meiotic recombination
GO:2000269--P:regulation of fibroblast apoptotic process
GO:0010332--P:response to gamma radiation
GO:0010212--P:response to ionizing radiation
GO:0010165--P:response to X-ray
GO:0001756--P:somitogenesis
GO:0042148--P:strand invasion