| Tag |
Content |
| dbPAF ID |
dbPAF-0001570 |
| Uniprot Accession |
O43542; XRCC3_HUMAN; O43568; Q9BU18;
|
| Genbank Protein ID |
NP_001093588.1; NP_001093589.1; NP_005423.1; XP_005268103.1; XP_011535440.1;
|
| Genbank Nucleotide ID |
NM_001100118.1; NM_001100119.1; NM_005432.3; XM_005268046.1; XM_011537138.1;
|
| Protein Name |
DNA repair protein XRCC3 |
| Protein Synonyms/Alias |
X-ray repair cross-complementing protein 3; |
| Gene Name |
XRCC3 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.Functional Description
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MDLDLLDLNP RIIAAIKKAK LKSVKEVLHF SGPDLKRLTN LSSPEVWHLL RTASLHLRGS 60
SILTALQLHQ QKERFPTQHQ RLSLGCPVLD ALLRGGLPLD GITELAGRSS AGKTQLALQL 120
CLAVQFPRQH GGLEAGAVYI CTEDAFPHKR LQQLMAQQPR LRTDVPGELL QKLRFGSQIF 180
IEHVADVDTL LECVNKKVPV LLSRGMARLV VIDSVAAPFR CEFDSQASAP RARHLQSLGA 240
TLRELSSAFQ SPVLCINQVT EAMEEQGAAH GPLGFWDERV SPALGITWAN QLLVRLLADR 300
LREEEAALGC PARTLRVLSA PHLPPSSCSY TISAEGVRGT PGTQSH
347Fasta Sequence
>O43542|XRCC3|Homo sapiens(Human)
MDLDLLDLNPRIIAAIKKAKLKSVKEVLHFSGPDLKRLTNLSSPEVWHLLRTASLHLRGSSILTALQLHQQKERFPTQHQRLSLGCPVLDALLRGGLPLDGITELAGRSSAGKTQLALQLCLAVQFPRQHGGLEAGAVYICTEDAFPHKRLQQLMAQQPRLRTDVPGELLQKLRFGSQIFIEHVADVDTLLECVNKKVPVLLSRGMARLVVIDSVAAPFRCEFDSQASAPRARHLQSLGATLRELSSAFQSPVLCINQVTEAMEEQGAAHGPLGFWDERVSPALGITWANQLLVRLLADRLREEEAALGCPARTLRVLSAPHLPPSSCSYTISAEGVRGTPGTQSH
|
| Keyword |
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
|
| Interpro |
IPR013632--DNA_recomb/repair_Rad51_C
IPR016467--DNA_recomb/repair_RecA-like
IPR027417--P-loop_NTPase
IPR020588--RecA_ATP-bd
|
| PROSITE |
PS50162--RECA_2
|
| Pfam |
PF08423--Rad51
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0033063--C:Rad51B-Rad51C-Rad51D-XRCC2 complex
GO:0033065--C:Rad51C-XRCC3 complex
GO:0005657--C:replication fork
GO:0005524--F:ATP binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0003690--F:double-stranded DNA binding
GO:0000150--F:recombinase activity
GO:0003697--F:single-stranded DNA binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0006302--P:double-strand break repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0045003--P:double-strand break repair via synthesis-dependent strand annealing
GO:0000707--P:meiotic DNA recombinase assembly
GO:0090267--P:positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0007131--P:reciprocal meiotic recombination
GO:0010824--P:regulation of centrosome duplication
GO:0071140--P:resolution of mitotic recombination intermediates
GO:0010212--P:response to ionizing radiation
GO:0010033--P:response to organic substance
GO:0042148--P:strand invasion
|
