| Tag |
Content |
| dbPAF ID |
dbPAF-0001569 |
| Uniprot Accession |
O43541; SMAD6_HUMAN; A9J6M5; O43654; Q15799; Q7Z7L4; Q96E31; Q9UKZ3;
|
| Genbank Protein ID |
NP_005576.3; XP_011519863.1;
|
| Genbank Nucleotide ID |
NM_005585.4; XM_011521561.1;
|
| Protein Name |
Mothers against decapentaplegic homolog 6 |
| Protein Synonyms/Alias |
|
| Gene Name |
SMAD6 |
| Gene Synonyms/Alias |
MADH6; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.Functional Description
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MFRSKRSGLV RRLWRSRVVP DREEGGSGGG GGGDEDGSLG SRAEPAPRAR EGGGCGRSEV 60
RPVAPRRPRD AVGQRGAQGA GRRRRAGGPP RPMSEPGAGA GSSLLDVAEP GGPGWLPESD 120
CETVTCCLFS ERDAAGAPRD ASDPLAGAAL EPAGGGRSRE ARSRLLLLEQ ELKTVTYSLL 180
KRLKERSLDT LLEAVESRGG VPGGCVLVPR ADLRLGGQPA PPQLLLGRLF RWPDLQHAVE 240
LKPLCGCHSF AAAADGPTVC CNPYHFSRLC GPESPPPPYS RLSPRDEYKP LDLSDSTLSY 300
TETEATNSLI TAPGEFSDAS MSPDATKPSH WCSVAYWEHR TRVGRLYAVY DQAVSIFYDL 360
PQGSGFCLGQ LNLEQRSESV RRTRSKIGFG ILLSKEPDGV WAYNRGEHPI FVNSPTLDAP 420
GGRALVVRKV PPGYSIKVFD FERSGLQHAP EPDAADGPYD PNSVRISFAK GWGPCYSRQF 480
ITSCPCWLEI LLNNPR
497Fasta Sequence
>O43541|SMAD6|Homo sapiens(Human)
MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
|
| Interpro |
IPR013790--Dwarfin
IPR003619--MAD_homology1_Dwarfin-type
IPR013019--MAD_homology_MH1
IPR017855--SMAD_dom-like
IPR001132--SMAD_dom_Dwarfin-type
IPR008984--SMAD_FHA_domain
|
| PROSITE |
PS51075--MH1
PS51076--MH2
|
| Pfam |
PF03165--MH1
PF03166--MH2
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0070410--F:co-SMAD binding
GO:0070411--F:I-SMAD binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0070412--F:R-SMAD binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0030617--F:transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0070698--F:type I activin receptor binding
GO:0034713--F:type I transforming growth factor beta receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0030509--P:BMP signaling pathway
GO:0031589--P:cell-substrate adhesion
GO:0045444--P:fat cell differentiation
GO:0006955--P:immune response
GO:0035556--P:intracellular signal transduction
GO:0043066--P:negative regulation of apoptotic process
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0060394--P:negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0010991--P:negative regulation of SMAD protein complex assembly
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0043627--P:response to estrogen
GO:0034616--P:response to laminar fluid shear stress
GO:0006351--P:transcription, DNA-templated
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0001657--P:ureteric bud development
GO:0007352--P:zygotic specification of dorsal/ventral axis
|
