dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001568
Uniprot Accession O43529; CHSTA_HUMAN; Q53T18;
Genbank Protein ID NP_004845.1; XP_011510509.1; XP_011510510.1; XP_011510511.1; XP_011510512.1; XP_011510513.1; XP_011510514.1;
Genbank Nucleotide ID NM_004854.4; XM_011512207.1; XM_011512208.1; XM_011512209.1; XM_011512210.1; XM_011512211.1; XM_011512212.1;
Protein Name Carbohydrate sulfotransferase 10
Protein Synonyms/Alias HNK-1 sulfotransferase;HNK-1ST;HNK1ST;HuHNK-1ST;
Gene Name CHST10
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
328EHYFLGISKRDIRRLPhosphoSitePlus22135298
348GDFKLFGYQKPDFLLdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MHHQWLLLAA CFWVIFMFMV ASKFITLTFK DPDVYSAKQE FLFLTTMPEV RKLPEEKHIP 60
EELKPTGKEL PDSQLVQPLV YMERLELIRN VCRDDALKNL SHTPVSKFVL DRIFVCDKHK 120
ILFCQTPKVG NTQWKKVLIV LNGAFSSIEE IPENVVHDHE KNGLPRLSSF SDAEIQKRLK 180
TYFKFFIVRD PFERLISAFK DKFVHNPRFE PWYRHEIAPG IIRKYRRNRT ETRGIQFEDF 240
VRYLGDPNHR WLDLQFGDHI IHWVTYVELC APCEIMYSVI GHHETLEDDA PYILKEAGID 300
HLVSYPTIPP GITVYNRTKV EHYFLGISKR DIRRLYARFE GDFKLFGYQK PDFLLN 357
Keyword

KW-0119--Carbohydrate metabolism
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0735--Signal-anchor
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR018011--Carb_sulfotransferase-rel
IPR005331--Sulfotransferase
PROSITE
Pfam

PF03567--Sulfotransfer_2
Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0008146--F:sulfotransferase activity
GO:0016051--P:carbohydrate biosynthetic process
GO:0007155--P:cell adhesion
GO:0007612--P:learning
GO:0007616--P:long-term memory