dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001567
Uniprot Accession O43526; KCNQ2_HUMAN; O43796; O75580; O95845; Q4VXP4; Q4VXR6; Q5VYT8; Q96J59; Q99454;
Genbank Protein ID NP_004509.2; NP_742104.1; NP_742105.1; NP_742106.1; NP_742107.1;
Genbank Nucleotide ID NM_004518.4; NM_172106.1; NM_172107.2; NM_172108.3; NM_172109.1;
Protein Name Potassium voltage-gated channel subfamily KQT member 2
Protein Synonyms/Alias KQT-like 2;Neuroblastoma-specific potassium channel subunit alpha KvLQT2;Voltage-gated potassium channel subunit Kv7.2;
Gene Name KCNQ2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.
Phosphorylation Sites
 dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
52SEAPKRGSILSKPRAdbPTM 3.0;PhosphoSitePlus9872318; 16381945; 23193290; 22135298
74PPKRNAFYRKLQNFLdbPTM 3.0;PhosphoSitePlus18083107; 16381945; 23193290; 22135298
217RMDRRGGTWKLLGSVPhosphoSitePlus;UniProt22135298; 16319223
229GSVVYAHSKELVTAWPhosphoSitePlus22135298
237KELVTAWYIGFLCLIPhosphoSitePlus22135298
372RTVTVPMYSSQTQTYdbPTM 3.0;PhosphoSitePlus18083107; 16381945; 23193290; 22135298
379YSSQTQTYGASRLIPPhosphoSitePlus22135298
438GRSSQKVSLKDRVFSPhosphoSitePlus22135298
445SLKDRVFSSPRGVAAPhosphoSitePlus22135298
507GAASRQNSEEASLPGPhosphoSitePlus22135298
539LTPGLKVSIRAVCVMPhosphoSitePlus22135298
551CVMRFLVSKRKFKESdbPTM 3.0;HPRD 912754513; 16381945; 23193290; 18988627
558SKRKFKESLRPYDVMdbPTM 3.0;HPRD 912754513; 16381945; 23193290; 18988627
562FKESLRPYDVMDVIEPhosphoSitePlus22135298
571VMDVIEQYSAGHLDMPhosphoSitePlus22135298
644LDFLVNIYMQRMGIPPhosphoSitePlus22135298
658PPTETEAYFGAKEPEPhosphoSitePlus22135298
755HERSLSAYGGGNRASPhosphoSitePlus22135298
821LDALNSCYAAVAPCAPhosphoSitePlus22135298
843EGESDTDSDLCTPCGPhosphoSitePlus22135298
Sequence
(Fasta)		MVQKSRNGGV YPGPSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSILSKPRAG 60
GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 120
SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 180
AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 240
LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 300
GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 360
QYYERTVTVP MYSSQTQTYG ASRLIPPLNQ LELLRNLKSK SGLAFRKDPP PEPSPSKGSP 420
CRGPLCGCCP GRSSQKVSLK DRVFSSPRGV AAKGKGSPQA QTVRRSPSAD QSLEDSPSKV 480
PKSWSFGDRS RARQAFRIKG AASRQNSEEA SLPGEDIVDD KSCPCEFVTE DLTPGLKVSI 540
RAVCVMRFLV SKRKFKESLR PYDVMDVIEQ YSAGHLDMLS RIKSLQSRVD QIVGRGPAIT 600
DKDRTKGPAE AELPEDPSMM GRLGKVEKQV LSMEKKLDFL VNIYMQRMGI PPTETEAYFG 660
AKEPEPAPPY HSPEDSREHV DRHGCIVKIV RSSSSTGQKN FSAPPAAPPV QCPPSTSWQP 720
QSHPRQGHGT SPVGDHGSLV RIPPPPAHER SLSAYGGGNR ASMEFLRQED TPGCRPPEGN 780
LRDSDTSISI PSVDHEELER SFSGFSISQS KENLDALNSC YAAVAPCAKV RPYIAEGESD 840
TDSDLCTPCG PPPRSATGEG PFGDVGWAGP RK 873
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0887--Epilepsy
KW-0407--Ion channel
KW-0406--Ion transport
KW-0472--Membrane
KW-0991--Mental retardation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0630--Potassium
KW-0631--Potassium channel
KW-0633--Potassium transport
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0851--Voltage-gated channel
Interpro

IPR020969--Ankyrin-G_BS
IPR005821--Ion_trans_dom
IPR003937--K_chnl_volt-dep_KCNQ
IPR003947--K_chnl_volt-dep_KCNQ2
IPR013821--K_chnl_volt-dep_KCNQ_C
IPR028325--VG_K_chnl
PROSITE
Pfam

PF00520--Ion_trans
PF03520--KCNQ_channel
PF11956--KCNQC3-Ank-G_bd
Gene Ontology

GO:0043194--C:axon initial segment
GO:0016021--C:integral component of membrane
GO:0033268--C:node of Ranvier
GO:0005886--C:plasma membrane
GO:0008076--C:voltage-gated potassium channel complex
GO:0030506--F:ankyrin binding
GO:0005251--F:delayed rectifier potassium channel activity
GO:0005267--F:potassium channel activity
GO:0005249--F:voltage-gated potassium channel activity
GO:0007411--P:axon guidance
GO:0007399--P:nervous system development
GO:0071805--P:potassium ion transmembrane transport
GO:0006813--P:potassium ion transport
GO:0007268--P:synaptic transmission
GO:0019226--P:transmission of nerve impulse