dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001566
Uniprot Accession O43525; KCNQ3_HUMAN; A2VCT8; B4DJY4; E7EQ89;
Genbank Protein ID NP_001191753.1; NP_004510.1;
Genbank Nucleotide ID NM_001204824.1; NM_004519.3;
Protein Name Potassium voltage-gated channel subfamily KQT member 3
Protein Synonyms/Alias KQT-like 3;Potassium channel subunit alpha KvLQT3;Voltage-gated potassium channel subunit Kv7.3;
Gene Name KCNQ3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
125PRGWALLYHALVFLIdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20058876; 16381945; 23193290; 18988627; 22135298; 22817900
184AAGCCCRYKGWRGRLPhosphoSitePlus22135298
246RMDRRGGTWKLLGSAdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;UniProt;curated16319223; 16381945; 23193290; 22135298; 22817900
481TAFRMKAYAFWQSSEPhosphoSitePlus22135298
502PMAEDRGYGNDFPIEdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
578IFTPGPPSTPKHKKSdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16319223; 16381945; 23193290; 22135298; 22817900; 24260401
579FTPGPPSTPKHKKSQdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16319223; 16381945; 23193290; 22135298; 22817900
663EYYPTKGTSSPAEAEPhosphoSitePlus22135298
664YYPTKGTSSPAEAEKPhosphoSitePlus22135298
665YPTKGTSSPAEAEKKPhosphoSitePlus22135298
746TTYVERPTVLPILTLdbPTM 3.0;HPRD 9;PhosphoSitePlus17924679; 16381945; 23193290; 18988627; 22135298
770QADLQGPYSDRISPRPhosphoSitePlus22135298
771ADLQGPYSDRISPRQPhosphoSitePlus22135298
810SPSGFSISQDRDDYVPhosphoSitePlus22135298
Sequence
(Fasta)		MGLKARRAAG AAGGGGDGGG GGGGAANPAG GDAAAAGDEE RKVGLAPGDV EQVTLALGAG 60
ADKDGTLLLE GGGRDEGQRR TPQGIGLLAK TPLSRPVKRN NAKYRRIQTL IYDALERPRG 120
WALLYHALVF LIVLGCLILA VLTTFKEYET VSGDWLLLLE TFAIFIFGAE FALRIWAAGC 180
CCRYKGWRGR LKFARKPLCM LDIFVLIASV PVVAVGNQGN VLATSLRSLR FLQILRMLRM 240
DRRGGTWKLL GSAICAHSKE LITAWYIGFL TLILSSFLVY LVEKDVPEVD AQGEEMKEEF 300
ETYADALWWG LITLATIGYG DKTPKTWEGR LIAATFSLIG VSFFALPAGI LGSGLALKVQ 360
EQHRQKHFEK RRKPAAELIQ AAWRYYATNP NRIDLVATWR FYESVVSFPF FRKEQLEAAS 420
SQKLGLLDRV RLSNPRGSNT KGKLFTPLNV DAIEESPSKE PKPVGLNNKE RFRTAFRMKA 480
YAFWQSSEDA GTGDPMAEDR GYGNDFPIED MIPTLKAAIR AVRILQFRLY KKKFKETLRP 540
YDVKDVIEQY SAGHLDMLSR IKYLQTRIDM IFTPGPPSTP KHKKSQKGSA FTFPSQQSPR 600
NEPYVARPST SEIEDQSMMG KFVKVERQVQ DMGKKLDFLV DMHMQHMERL QVQVTEYYPT 660
KGTSSPAEAE KKEDNRYSDL KTIICNYSET GPPEPPYSFH QVTIDKVSPY GFFAHDPVNL 720
PRGGPSSGKV QATPPSSATT YVERPTVLPI LTLLDSRVSC HSQADLQGPY SDRISPRQRR 780
SITRDSDTPL SLMSVNHEEL ERSPSGFSIS QDRDDYVFGP NGGSSWMREK RYLAEGETDT 840
DTDPFTPSGS MPLSSTGDGI SDSVWTPSNK PI 873
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0887--Epilepsy
KW-0407--Ion channel
KW-0406--Ion transport
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0630--Potassium
KW-0631--Potassium channel
KW-0633--Potassium transport
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0851--Voltage-gated channel
Interpro

IPR020969--Ankyrin-G_BS
IPR005821--Ion_trans_dom
IPR003937--K_chnl_volt-dep_KCNQ
IPR003948--K_chnl_volt-dep_KCNQ3
IPR013821--K_chnl_volt-dep_KCNQ_C
IPR028325--VG_K_chnl
PROSITE
Pfam

PF00520--Ion_trans
PF03520--KCNQ_channel
PF11956--KCNQC3-Ank-G_bd
Gene Ontology

GO:0043194--C:axon initial segment
GO:0009986--C:cell surface
GO:0030425--C:dendrite
GO:0016021--C:integral component of membrane
GO:0045121--C:membrane raft
GO:0043025--C:neuronal cell body
GO:0033268--C:node of Ranvier
GO:0005886--C:plasma membrane
GO:0008076--C:voltage-gated potassium channel complex
GO:0005251--F:delayed rectifier potassium channel activity
GO:0005267--F:potassium channel activity
GO:0005249--F:voltage-gated potassium channel activity
GO:0007411--P:axon guidance
GO:0071242--P:cellular response to ammonium ion
GO:0061548--P:ganglion development
GO:0060081--P:membrane hyperpolarization
GO:0014003--P:oligodendrocyte development
GO:0071805--P:potassium ion transmembrane transport
GO:0006813--P:potassium ion transport
GO:0007268--P:synaptic transmission