Functional Description
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Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.Functional Description
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. |
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031490--F:chromatin DNA binding
GO:0001047--F:core promoter binding
GO:0003677--F:DNA binding
GO:0019901--F:protein kinase binding
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0009653--P:anatomical structure morphogenesis
GO:0001547--P:antral ovarian follicle growth
GO:0030154--P:cell differentiation
GO:0034599--P:cellular response to oxidative stress
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0097192--P:extrinsic apoptotic signaling pathway in absence of ligand
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0042593--P:glucose homeostasis
GO:0001544--P:initiation of primordial ovarian follicle growth
GO:0045087--P:innate immune response
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0097150--P:neuronal stem cell population maintenance
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0001556--P:oocyte maturation
GO:0001542--P:ovulation from ovarian follicle
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0043065--P:positive regulation of apoptotic process
GO:0045648--P:positive regulation of erythrocyte differentiation
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:2000177--P:regulation of neural precursor cell proliferation
GO:2000377--P:regulation of reactive oxygen species metabolic process
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006417--P:regulation of translation
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
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