dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001564
Uniprot Accession O43521; B2L11_HUMAN; A8K2W2; O43522; Q0MSE7; Q0MSE8; Q0MSE9; Q53R28; Q6JTU6; Q6T851; Q6TE14; Q6TE15; Q6TE16; Q6V402; Q8WYL6; Q8WYL7; Q8WYL8; Q8WYL9; Q8WYM0; Q8WYM1;
Genbank Protein ID NP_001191035.1; NP_001191036.1; NP_001191037.1; NP_001191038.1; NP_001191039.1; NP_001191040.1; NP_001191041.1; NP_001191042.1; NP_006529.1; NP_619527.1; NP_619528.1; NP_619529.1; NP_619530.1; NP_619531.1; NP_619532.1; NP_619533.1; NP_996885.1; NP_996886.1;
Genbank Nucleotide ID NM_001204106.1; NM_001204107.1; NM_001204108.1; NM_001204109.1; NM_001204110.1; NM_001204111.1; NM_001204112.1; NM_001204113.1; NM_006538.4; NM_138621.4; NM_138622.3; NM_138623.3; NM_138624.3; NM_138625.3; NM_138626.3; NM_138627.3; NM_207002.3; NM_207003.2;
Protein Name Bcl-2-like protein 11
Protein Synonyms/Alias
Gene Name BCL2L11
Gene Synonyms/Alias BIM;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Phosphorylation Sites
dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
34QLRPGAPTSLQTEPQPhosphoSitePlus22135298
35LRPGAPTSLQTEPQGPhosphoSitePlus22135298
38GAPTSLQTEPQGNPEPhosphoSitePlus22135298
59GDSCPHGSPQGPLAPdbPTM 3.0;HPRD 9;PhosphoSitePlus21924351; 16381945; 23193290; 12818176; 18988627; 22135298
69GPLAPPASPGPFATRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated14555991; 15486195; 16381945; 23193290; 14676826; 17525735;
77PGPFATRSPLFIFMRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18220336; 18691976; 16381945; 23193290; 19276368; 21924351;
87FIFMRRSSLLSRSSSdbPTM 3.0;PhosphoSitePlus;curated16282323; 16381945; 23193290; 22135298; 23911959; 23090842;
90MRRSSLLSRSSSGYFcurated23090842
93SSLLSRSSSGYFSFDPhosphoSitePlus22135298
94SLLSRSSSGYFSFDTdbPTM 3.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 22135298; 23917254; 22817900;
98RSSSGYFSFDTDRSPPhosphoSitePlus22135298
104FSFDTDRSPAPMSCDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus12591950; 16381945; 23193290; 21924351; 18988627; 22135298
113APMSCDKSTQTPSPPPhosphoSitePlus22135298
116SCDKSTQTPSPPCQAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated12591950; 16381945; 23193290; 14676826; 21924351; 18988627;
118DKSTQTPSPPCQAFNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated12591950; 16381945; 23193290; 14676826; 21924351; 18988627;
Sequence
(Fasta)
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP 60
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP 120
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR 180
MVILRLLRYI VRLVWRMH 199
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR014771--Apoptosis_Bim_N
IPR017288--Bcl-2-like_11
IPR015040--Bcl-x_interacting_BH3_dom

PROSITE
Pfam

PF08945--Bclx_interact
PF06773--Bim_N

Gene Ontology

GO:0097141--C:BIM-BCL-2 complex
GO:0097140--C:BIM-BCL-xl complex
GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0019898--C:extrinsic component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915--P:apoptotic process
GO:1902263--P:apoptotic process involved in embryonic digit morphogenesis
GO:0097190--P:apoptotic signaling pathway
GO:0001783--P:B cell apoptotic process
GO:0001782--P:B cell homeostasis
GO:0007420--P:brain development
GO:0007160--P:cell-matrix adhesion
GO:0060154--P:cellular process regulating host cell cycle in response to virus
GO:0048066--P:developmental pigmentation
GO:0043583--P:ear development
GO:0097192--P:extrinsic apoptotic signaling pathway in absence of ligand
GO:0001701--P:in utero embryonic development
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001822--P:kidney development
GO:0008584--P:male gonad development
GO:0030879--P:mammary gland development
GO:0002262--P:myeloid cell homeostasis
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0043065--P:positive regulation of apoptotic process
GO:0060139--P:positive regulation of apoptotic process by virus
GO:0045787--P:positive regulation of cell cycle
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2000271--P:positive regulation of fibroblast apoptotic process
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:1903896--P:positive regulation of IRE1-mediated unfolded protein response
GO:1902110--P:positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0032464--P:positive regulation of protein homooligomerization
GO:1900740--P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0090200--P:positive regulation of release of cytochrome c from mitochondria
GO:0048563--P:post-embryonic organ morphogenesis
GO:0012501--P:programmed cell death
GO:0048070--P:regulation of developmental pigmentation
GO:0046620--P:regulation of organ growth
GO:0034976--P:response to endoplasmic reticulum stress
GO:0007283--P:spermatogenesis
GO:0048536--P:spleen development
GO:0043029--P:T cell homeostasis
GO:0070242--P:thymocyte apoptotic process
GO:0048538--P:thymus development
GO:0035148--P:tube formation