dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001561
Uniprot Accession O43513; MED7_HUMAN;
Genbank Protein ID NP_001094286.1; NP_004261.1;
Genbank Nucleotide ID NM_001100816.1; NM_004270.4;
Protein Name Mediator of RNA polymerase II transcription subunit 7
Protein Synonyms/Alias
Gene Name MED7
Gene Synonyms/Alias ARC34;CRSP9;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
194EPMDADDSNNCTGQNdbPTM 3.0;PHOSIDA;PhosphoSitePlus;UniProt;curated19369195; 16381945; 23193290; 21081558; 22135298; 23898821;
198ADDSNNCTGQNEHQRPhosphoSitePlus22135298
Sequence
(Fasta)		MGEPQQVSAL PPPPMQYIKE YTDENIQEGL APKPPPPIKD SYMMFGNQFQ CDDLIIRPLE 60
SQGIERLHPM QFDHKKELRK LNMSILINFL DLLDILIRSP GSIKREEKLE DLKLLFVHVH 120
HLINEYRPHQ ARETLRVMME VQKRQRLETA ERFQKHLERV IEMIQNCLAS LPDDLPHSEA 180
GMRVKTEPMD ADDSNNCTGQ NEHQRENSGH RRDQIIEKDA ALCVLIDEMN ERP 234
Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR009244--Mediatior_Med7
PROSITE
Pfam

PF05983--Med7
Gene Ontology

GO:0016592--C:mediator complex
GO:0005654--C:nucleoplasm
GO:0005667--C:transcription factor complex
GO:0000151--C:ubiquitin ligase complex
GO:0001104--F:RNA polymerase II transcription cofactor activity
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0010467--P:gene expression
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0019827--P:stem cell population maintenance
GO:0006367--P:transcription initiation from RNA polymerase II promoter