| Tag |
Content |
| dbPAF ID |
dbPAF-0001560 |
| Uniprot Accession |
O43511; S26A4_HUMAN; B7Z266; O43170;
|
| Genbank Protein ID |
NP_000432.1; XP_005250482.1;
|
| Genbank Nucleotide ID |
NM_000441.1; XM_005250425.1;
|
| Protein Name |
Pendrin |
| Protein Synonyms/Alias |
Sodium-independent chloride/iodide transporter;Solute carrier family 26 member 4; |
| Gene Name |
SLC26A4 |
| Gene Synonyms/Alias |
PDS; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Sodium-independent transporter of chloride and iodide.Functional Description
Sodium-independent transporter of chloride and iodide. |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MAAPGGRSEP PQLPEYSCSY MVSRPVYSEL AFQQQHERRL QERKTLRESL AKCCSCSRKR 60
AFGVLKTLVP ILEWLPKYRV KEWLLSDVIS GVSTGLVATL QGMAYALLAA VPVGYGLYSA 120
FFPILTYFIF GTSRHISVGP FPVVSLMVGS VVLSMAPDEH FLVSSSNGTV LNTTMIDTAA 180
RDTARVLIAS ALTLLVGIIQ LIFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL 240
NVSTKNYNGV LSIIYTLVEI FQNIGDTNLA DFTAGLLTIV VCMAVKELND RFRHKIPVPI 300
PIEVIVTIIA TAISYGANLE KNYNAGIVKS IPRGFLPPEL PPVSLFSEML AASFSIAVVA 360
YAIAVSVGKV YATKYDYTID GNQEFIAFGI SNIFSGFFSC FVATTALSRT AVQESTGGKT 420
QVAGIISAAI VMIAILALGK LLEPLQKSVL AAVVIANLKG MFMQLCDIPR LWRQNKIDAV 480
IWVFTCIVSI ILGLDLGLLA GLIFGLLTVV LRVQFPSWNG LGSIPSTDIY KSTKNYKNIE 540
EPQGVKILRF SSPIFYGNVD GFKKCIKSTV GFDAIRVYNK RLKALRKIQK LIKSGQLRAT 600
KNGIISDAVS TNNAFEPDED IEDLEELDIP TKEIEIQVDW NSELPVKVNV PKVPIHSLVL 660
DCGAISFLDV VGVRSLRVIV KEFQRIDVNV YFASLQDYVI EKLEQCGFFD DNIRKDTFFL 720
TVHDAILYLQ NQVKSQEGQG SILETITLIQ DCKDTLELIE TELTEEELDV QDEAMRTLAS 780
781Fasta Sequence
>O43511|SLC26A4|Homo sapiens(Human)
MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS
|
| Keyword |
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0868--Chloride
KW-0181--Complete proteome
KW-0209--Deafness
KW-0225--Disease mutation
KW-0472--Membrane
KW-1010--Non-syndromic deafness
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR030285--Pendrin
IPR018045--S04_transporter_CS
IPR011547--SLC26A/SulP_dom
IPR001902--SLC26A/SulP_fam
IPR002645--STAS_dom
|
| PROSITE |
PS01130--SLC26A
PS50801--STAS
|
| Pfam |
PF01740--STAS
PF00916--Sulfate_transp
|
| Gene Ontology |
GO:0016324--C:apical plasma membrane
GO:0031526--C:brush border membrane
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0015301--F:anion:anion antiporter activity
GO:0015106--F:bicarbonate transmembrane transporter activity
GO:0005254--F:chloride channel activity
GO:0015108--F:chloride transmembrane transporter activity
GO:0015111--F:iodide transmembrane transporter activity
GO:0019531--F:oxalate transmembrane transporter activity
GO:0008271--F:secondary active sulfate transmembrane transporter activity
GO:0015116--F:sulfate transmembrane transporter activity
GO:0015701--P:bicarbonate transport
GO:1902476--P:chloride transmembrane transport
GO:0015698--P:inorganic anion transport
GO:0006811--P:ion transport
GO:0019532--P:oxalate transport
GO:0051453--P:regulation of intracellular pH
GO:0042391--P:regulation of membrane potential
GO:0006885--P:regulation of pH
GO:0032880--P:regulation of protein localization
GO:0007605--P:sensory perception of sound
GO:1902358--P:sulfate transmembrane transport
GO:0008272--P:sulfate transport
GO:0055085--P:transmembrane transport
|
