| Tag |
Content |
| dbPAF ID |
dbPAF-0001559 |
| Uniprot Accession |
O43508; TNF12_HUMAN; Q8IZK7; Q8WUZ7;
|
| Genbank Protein ID |
NP_003800.1; NP_742086.1;
|
| Genbank Nucleotide ID |
NM_003809.2; NM_172089.3;
|
| Protein Name |
Tumor necrosis factor ligand superfamily member 12 |
| Protein Synonyms/Alias |
APO3 ligand;TNF-related weak inducer of apoptosis;TWEAK; |
| Gene Name |
TNFSF12 |
| Gene Synonyms/Alias |
APO3L;DR3LG;UNQ181/PRO207; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.Functional Description
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MAARRSQRRR GRRGEPGTAL LVPLALGLGL ALACLGLLLA VVSLGSRASL SAQEPAQEEL 60
VAEEDQDPSE LNPQTEESQD PAPFLNRLVR PRRSAPKGRK TRARRAIAAH YEVHPRPGQD 120
GAQAGVDGTV SGWEEARINS SSPLRYNRQI GEFIVTRAGL YYLYCQVHFD EGKAVYLKLD 180
LLVDGVLALR CLEEFSATAA SSLGPQLRLC QVSGLLALRP GSSLRIRTLP WAHLKAAPFL 240
TYFGLFQVH
Fasta Sequence
>O43508|TNFSF12|Homo sapiens(Human)
MAARRSQRRRGRRGEPGTALLVPLALGLGLALACLGLLLAVVSLGSRASLSAQEPAQEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDGVLALRCLEEFSATAASSLGPQLRLCQVSGLLALRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0037--Angiogenesis
KW-0053--Apoptosis
KW-1003--Cell membrane
KW-0165--Cleavage on pair of basic residues
KW-0181--Complete proteome
KW-0202--Cytokine
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0472--Membrane
KW-1185--Reference proteome
KW-0964--Secreted
KW-0735--Signal-anchor
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR006052--TNF_dom
IPR008983--Tumour_necrosis_fac-like_dom
|
| PROSITE |
PS50049--TNF_2
|
| Pfam |
PF00229--TNF
|
| Gene Ontology |
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005887--C:integral component of plasma membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005125--F:cytokine activity
GO:0005102--F:receptor binding
GO:0001525--P:angiogenesis
GO:0006915--P:apoptotic process
GO:0097190--P:apoptotic signaling pathway
GO:0030154--P:cell differentiation
GO:0043542--P:endothelial cell migration
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0006955--P:immune response
GO:0045766--P:positive regulation of angiogenesis
GO:0001938--P:positive regulation of endothelial cell proliferation
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045732--P:positive regulation of protein catabolic process
GO:0007165--P:signal transduction
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
|
