Tag |
Content |
dbPAF ID |
dbPAF-0001558 |
Uniprot Accession |
O43506; ADA20_HUMAN; Q6GTZ1; Q9UKJ9; |
Genbank Protein ID |
NP_003805.3; XP_005268208.1; XP_005268209.1; XP_011535575.1; XP_011535576.1; |
Genbank Nucleotide ID |
NM_003814.4; XM_005268151.2; XM_005268152.2; XM_011537273.1; XM_011537274.1; |
Protein Name |
Disintegrin and metalloproteinase domain-containing protein 20 |
Protein Synonyms/Alias |
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Gene Name |
ADAM20 |
Gene Synonyms/Alias |
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Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
May be involved in sperm maturation and/or fertilization.Functional Description
May be involved in sperm maturation and/or fertilization.
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Phosphorylation Sites
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dbPAF PTMs: 5 Position | Peptides | Source | References ( PMIDs ) |
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193 | LQLSYNFTLKQSSFV | PhosphoSitePlus | 22135298 | 312 | GMKLGVAYVKGICQN | PhosphoSitePlus | 22135298 | 531 | RSASQSCYQEINTQG | curated | 23663014 | 718 | HVLFKKRTKSKEDEE | PhosphoSitePlus | 22135298 | 720 | LFKKRTKSKEDEEG- | PhosphoSitePlus | 22135298 |
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Sequence (Fasta) | MAVGEPLVHI RVTLLLLWFG MFLSISGHSQ ARPSQYFTSP EVVIPLKVIS RGRGAKAPGW 60 LSYSLRFGGQ RYIVHMRVNK LLFAAHLPVF TYTEQHALLQ DQPFIQDDCY YHGYVEGVPE 120 SLVALSTCSG GFLGMLQIND LVYEIKPISV SATFEHLVYK IDSDDTQFPP MRCGLTEEKI 180 AHQMELQLSY NFTLKQSSFV GWWTHQRFVE LVVVVDNIRY LFSQSNATTV QHEVFNVVNI 240 VDSFYHPLEV DVILTGIDIW TASNPLPTSG DLDNVLEDFS IWKNYNLNNR LQHDVAHLFI 300 KDTQGMKLGV AYVKGICQNP FNTGVDVFED NRLVVFAITL GHELGHNLGM QHDTQWCVCE 360 LQWCIMHAYR KVTTKFSNCS YAQYWDSTIS SGLCIQPPPY PGNIFRLKYC GNLVVEEGEE 420 CDCGTIRQCA KDPCCLLNCT LHPGAACAFG ICCKDCKFLP SGTLCRQQVG ECDLPEWCNG 480 TSHQCPDDVY VQDGISCNVN AFCYEKTCNN HDIQCKEIFG QDARSASQSC YQEINTQGNR 540 FGHCGIVGTT YVKCWTPDIM CGRVQCENVG VIPNLIEHST VQQFHLNDTT CWGTDYHLGM 600 AIPDIGEVKD GTVCGPEKIC IRKKCASMVH LSQACQPKTC NMRGICNNKQ HCHCNHEWAP 660 PYCKDKGYGG SADSGPPPKN NMEGLNVMGK LRYLSLLCLL PLVAFLLFCL HVLFKKRTKS 720 KEDEEG
727Fasta Sequence
>O43506|ADAM20|Homo sapiens(Human) MAVGEPLVHIRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMHAYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKGYGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEEG
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Keyword |
KW-0181--Complete proteome KW-1015--Disulfide bond KW-0245--EGF-like domain KW-0325--Glycoprotein KW-0378--Hydrolase KW-0472--Membrane KW-0479--Metal-binding KW-0482--Metalloprotease KW-0645--Protease KW-1185--Reference proteome KW-0732--Signal KW-0812--Transmembrane KW-1133--Transmembrane helix KW-0862--Zinc KW-0865--Zymogen
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Interpro |
IPR006586--ADAM_Cys-rich IPR018358--Disintegrin_CS IPR001762--Disintegrin_dom IPR024079--MetalloPept_cat_dom IPR001590--Peptidase_M12B IPR002870--Peptidase_M12B_N
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PROSITE |
PS50215--ADAM_MEPRO PS00427--DISINTEGRIN_1 PS50214--DISINTEGRIN_2 PS00142--ZINC_PROTEASE
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Pfam |
PF08516--ADAM_CR PF00200--Disintegrin PF01562--Pep_M12B_propep PF01421--Reprolysin
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Gene Ontology |
GO:0016021--C:integral component of membrane GO:0005886--C:plasma membrane GO:0004222--F:metalloendopeptidase activity GO:0008237--F:metallopeptidase activity GO:0008270--F:zinc ion binding GO:0007339--P:binding of sperm to zona pellucida GO:0032504--P:multicellular organism reproduction GO:0007338--P:single fertilization
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