dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001558
Uniprot Accession O43506; ADA20_HUMAN; Q6GTZ1; Q9UKJ9;
Genbank Protein ID NP_003805.3; XP_005268208.1; XP_005268209.1; XP_011535575.1; XP_011535576.1;
Genbank Nucleotide ID NM_003814.4; XM_005268151.2; XM_005268152.2; XM_011537273.1; XM_011537274.1;
Protein Name Disintegrin and metalloproteinase domain-containing protein 20
Protein Synonyms/Alias
Gene Name ADAM20
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
May be involved in sperm maturation and/or fertilization.
Phosphorylation Sites
dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
193LQLSYNFTLKQSSFVPhosphoSitePlus22135298
312GMKLGVAYVKGICQNPhosphoSitePlus22135298
531RSASQSCYQEINTQGcurated23663014
718HVLFKKRTKSKEDEEPhosphoSitePlus22135298
720LFKKRTKSKEDEEG-PhosphoSitePlus22135298
Sequence
(Fasta)
MAVGEPLVHI RVTLLLLWFG MFLSISGHSQ ARPSQYFTSP EVVIPLKVIS RGRGAKAPGW 60
LSYSLRFGGQ RYIVHMRVNK LLFAAHLPVF TYTEQHALLQ DQPFIQDDCY YHGYVEGVPE 120
SLVALSTCSG GFLGMLQIND LVYEIKPISV SATFEHLVYK IDSDDTQFPP MRCGLTEEKI 180
AHQMELQLSY NFTLKQSSFV GWWTHQRFVE LVVVVDNIRY LFSQSNATTV QHEVFNVVNI 240
VDSFYHPLEV DVILTGIDIW TASNPLPTSG DLDNVLEDFS IWKNYNLNNR LQHDVAHLFI 300
KDTQGMKLGV AYVKGICQNP FNTGVDVFED NRLVVFAITL GHELGHNLGM QHDTQWCVCE 360
LQWCIMHAYR KVTTKFSNCS YAQYWDSTIS SGLCIQPPPY PGNIFRLKYC GNLVVEEGEE 420
CDCGTIRQCA KDPCCLLNCT LHPGAACAFG ICCKDCKFLP SGTLCRQQVG ECDLPEWCNG 480
TSHQCPDDVY VQDGISCNVN AFCYEKTCNN HDIQCKEIFG QDARSASQSC YQEINTQGNR 540
FGHCGIVGTT YVKCWTPDIM CGRVQCENVG VIPNLIEHST VQQFHLNDTT CWGTDYHLGM 600
AIPDIGEVKD GTVCGPEKIC IRKKCASMVH LSQACQPKTC NMRGICNNKQ HCHCNHEWAP 660
PYCKDKGYGG SADSGPPPKN NMEGLNVMGK LRYLSLLCLL PLVAFLLFCL HVLFKKRTKS 720
KEDEEG 727
Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0645--Protease
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0865--Zymogen

Interpro

IPR006586--ADAM_Cys-rich
IPR018358--Disintegrin_CS
IPR001762--Disintegrin_dom
IPR024079--MetalloPept_cat_dom
IPR001590--Peptidase_M12B
IPR002870--Peptidase_M12B_N

PROSITE

PS50215--ADAM_MEPRO
PS00427--DISINTEGRIN_1
PS50214--DISINTEGRIN_2
PS00142--ZINC_PROTEASE

Pfam

PF08516--ADAM_CR
PF00200--Disintegrin
PF01562--Pep_M12B_propep
PF01421--Reprolysin

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0004222--F:metalloendopeptidase activity
GO:0008237--F:metallopeptidase activity
GO:0008270--F:zinc ion binding
GO:0007339--P:binding of sperm to zona pellucida
GO:0032504--P:multicellular organism reproduction
GO:0007338--P:single fertilization