| Tag |
Content |
| dbPAF ID |
dbPAF-0001557 |
| Uniprot Accession |
O43505; B4GA1_HUMAN; Q4TTN0;
|
| Genbank Protein ID |
NP_006867.1;
|
| Genbank Nucleotide ID |
NM_006876.2;
|
| Protein Name |
Beta-1,4-glucuronyltransferase 1 |
| Protein Synonyms/Alias |
I-beta-1,3-N-acetylglucosaminyltransferase;iGnT;N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase;Poly-N-acetyllactosamine extension enzyme;UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1; |
| Gene Name |
B4GAT1 |
| Gene Synonyms/Alias |
B3GNT1;B3GNT6; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity).Functional Description
Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MQMSYAIRCA FYQLLLAALM LVAMLQLLYL SLLSGLHGQE EQDQYFEFFP PSPRSVDQVK 60
AQLRTALASG GVLDASGDYR VYRGLLKTTM DPNDVILATH ASVDNLLHLS GLLERWEGPL 120
SVSVFAATKE EAQLATVLAY ALSSHCPDMR ARVAMHLVCP SRYEAAVPDP REPGEFALLR 180
SCQEVFDKLA RVAQPGINYA LGTNVSYPNN LLRNLAREGA NYALVIDVDM VPSEGLWRGL 240
REMLDQSNQW GGTALVVPAF EIRRARRMPM NKNELVQLYQ VGEVRPFYYG LCTPCQAPTN 300
YSRWVNLPEE SLLRPAYVVP WQDPWEPFYV AGGKVPTFDE RFRQYGFNRI SQACELHVAG 360
FDFEVLNEGF LVHKGFKEAL KFHPQKEAEN QHNKILYRQF KQELKAKYPN SPRRC
416Fasta Sequence
>O43505|B4GAT1|Homo sapiens(Human)
MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQDQYFEFFPPSPRSVDQVKAQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPLSVSVFAATKEEAQLATVLAYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLRSCQEVFDKLARVAQPGINYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRGLREMLDQSNQWGGTALVVPAFEIRRARRMPMNKNELVQLYQVGEVRPFYYGLCTPCQAPTNYSRWVNLPEESLLRPAYVVPWQDPWEPFYVAGGKVPTFDERFRQYGFNRISQACELHVAGFDFEVLNEGFLVHKGFKEALKFHPQKEAENQHNKILYRQFKQELKAKYPNSPRRC
|
| Keyword |
KW-0181--Complete proteome
KW-0912--Congenital muscular dystrophy
KW-0225--Disease mutation
KW-1215--Dystroglycanopathy
KW-0325--Glycoprotein
KW-0328--Glycosyltransferase
KW-0333--Golgi apparatus
KW-0451--Lissencephaly
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0735--Signal-anchor
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
|
| PROSITE |
|
| Pfam |
|
| Gene Ontology |
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0030173--C:integral component of Golgi membrane
GO:0015020--F:glucuronosyltransferase activity
GO:0046872--F:metal ion binding
GO:0008532--F:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
GO:0007411--P:axon guidance
GO:0005975--P:carbohydrate metabolic process
GO:0030203--P:glycosaminoglycan metabolic process
GO:0018146--P:keratan sulfate biosynthetic process
GO:0042339--P:keratan sulfate metabolic process
GO:0030311--P:poly-N-acetyllactosamine biosynthetic process
GO:0035269--P:protein O-linked mannosylation
GO:0044281--P:small molecule metabolic process
|
