dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0001556 |
| Uniprot Accession | O43504; LTOR5_HUMAN; Q6IBD8; |
| Genbank Protein ID | NP_006393.2; |
| Genbank Nucleotide ID | NM_006402.2; |
| Protein Name | Ragulator complex protein LAMTOR5 |
| Protein Synonyms/Alias | Hepatitis B virus X-interacting protein;HBV X-interacting protein;HBX-interacting protein;Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5; |
| Gene Name | LAMTOR5 |
| Gene Synonyms/Alias | HBXIP;XIP; |
| Organism | Homo sapiens(Human) |
| NCBI Taxa ID | 9606 |
| Functional Description (View all) |
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. |
| Phosphorylation Sites |
dbPAF PTMs: 4 |
| Sequence (Fasta) | MEATLEQHLE DTMKNPSIVG VLCTDSQGLN LGCRGTLSDE HAGVISVLAQ QAAKLTSDPT 60 DIPVVCLESD NGNIMIQKHD GITVAVHKMA S 92 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR024135--LAMTOR5 |
| PROSITE | |
| Pfam | PF16672--LAMTOR5 |
| Gene Ontology | GO:0005829--C:cytosol |