dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001551
Uniprot Accession O43490; PROM1_HUMAN; Q6SV49; Q6SV50; Q6SV51; Q6SV52; Q6SV53; Q96EN6;
Genbank Protein ID NP_001139319.1; NP_001139320.1; NP_001139321.1; NP_001139322.1; NP_001139323.1; NP_001139324.1; NP_006008.1; XP_005248252.1; XP_005248253.1; XP_011512192.1; XP_011512193.1; XP_011512194.1; XP_011512195.1; XP_011512196.1; XP_011512197.1; XP_011512198.1; XP_011512199.1; XP_011512202.1; XP_011512204.1;
Genbank Nucleotide ID NM_001145847.1; NM_001145848.1; NM_001145849.1; NM_001145850.1; NM_001145851.1; NM_001145852.1; NM_006017.2; XM_005248195.3; XM_005248196.3; XM_011513890.1; XM_011513891.1; XM_011513892.1; XM_011513893.1; XM_011513894.1; XM_011513895.1; XM_011513896.1; XM_011513897.1; XM_011513900.1; XM_011513902.1;
Protein Name Prominin-1
Protein Synonyms/Alias Antigen AC133;Prominin-like protein 1;
Gene Name PROM1
Gene Synonyms/Alias PROML1;MSTP061;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
34DAPKAWNYELPATNYPhosphoSitePlus22135298
219IKYILAQYNTTKDKAPhosphoSitePlus22135298
266MATAIKETKEALENMdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.017081983; 16381945; 23193290; 18988627; 21081558; 22135298;
275EALENMNSTLKSLHQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.017081983; 16381945; 23193290; 18988627; 21081558; 22135298;
276ALENMNSTLKSLHQQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.017081983; 16381945; 23193290; 18988627; 21081558; 22135298;
719RVTRILASLDFAQNFPhosphoSitePlus22135298
733FITNNTSSVIIEETKPhosphoSitePlus22135298
739SSVIIEETKKYGRTIPhosphoSitePlus22135298
824KYYRRMDSEDVYDDVPhosphoSitePlus22135298
828RMDSEDVYDDVETIPdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus18083107; 19296573; 16381945; 23193290; 19060867; 22135298
852GYHKDHVYGIHNPVMdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus18083107; 19296573; 16381945; 23193290; 19060867; 22135298
863NPVMTSPSQH-----dbPTM 3.0;PhosphoSitePlus;UniProt21406692; 16381945; 23193290; 22135298
Sequence
(Fasta)		MALVLGSLLL LGLCGNSFSG GQPSSTDAPK AWNYELPATN YETQDSHKAG PIGILFELVH 60
IFLYVVQPRD FPEDTLRKFL QKAYESKIDY DKPETVILGL KIVYYEAGII LCCVLGLLFI 120
ILMPLVGYFF CMCRCCNKCG GEMHQRQKEN GPFLRKCFAI SLLVICIIIS IGIFYGFVAN 180
HQVRTRIKRS RKLADSNFKD LRTLLNETPE QIKYILAQYN TTKDKAFTDL NSINSVLGGG 240
ILDRLRPNII PVLDEIKSMA TAIKETKEAL ENMNSTLKSL HQQSTQLSSS LTSVKTSLRS 300
SLNDPLCLVH PSSETCNSIR LSLSQLNSNP ELRQLPPVDA ELDNVNNVLR TDLDGLVQQG 360
YQSLNDIPDR VQRQTTTVVA GIKRVLNSIG SDIDNVTQRL PIQDILSAFS VYVNNTESYI 420
HRNLPTLEEY DSYWWLGGLV ICSLLTLIVI FYYLGLLCGV CGYDRHATPT TRGCVSNTGG 480
VFLMVGVGLS FLFCWILMII VVLTFVFGAN VEKLICEPYT SKELFRVLDT PYLLNEDWEY 540
YLSGKLFNKS KMKLTFEQVY SDCKKNRGTY GTLHLQNSFN ISEHLNINEH TGSISSELES 600
LKVNLNIFLL GAAGRKNLQD FAACGIDRMN YDSYLAQTGK SPAGVNLLSF AYDLEAKANS 660
LPPGNLRNSL KRDAQTIKTI HQQRVLPIEQ SLSTLYQSVK ILQRTGNGLL ERVTRILASL 720
DFAQNFITNN TSSVIIEETK KYGRTIIGYF EHYLQWIEFS ISEKVASCKP VATALDTAVD 780
VFLCSYIIDP LNLFWFGIGK ATVFLLPALI FAVKLAKYYR RMDSEDVYDD VETIPMKNME 840
NGNNGYHKDH VYGIHNPVMT SPSQH 866
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0969--Cilium
KW-0181--Complete proteome
KW-0182--Cone-rod dystrophy
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0682--Retinitis pigmentosa
KW-0732--Signal
KW-0751--Stargardt disease
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR008795--Prominin
PROSITE
Pfam

PF05478--Prominin
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005903--C:brush border
GO:0009986--C:cell surface
GO:0005783--C:endoplasmic reticulum
GO:0005793--C:endoplasmic reticulum-Golgi intermediate compartment
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0005887--C:integral component of plasma membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0031528--C:microvillus membrane
GO:0001750--C:photoreceptor outer segment
GO:0042622--C:photoreceptor outer segment membrane
GO:0005886--C:plasma membrane
GO:0032420--C:stereocilium
GO:0031982--C:vesicle
GO:0042805--F:actinin binding
GO:0045296--F:cadherin binding
GO:0060219--P:camera-type eye photoreceptor cell differentiation
GO:0072139--P:glomerular parietal epithelial cell differentiation
GO:0072112--P:glomerular visceral epithelial cell differentiation
GO:0045494--P:photoreceptor cell maintenance
GO:2000768--P:positive regulation of nephron tubule epithelial cell differentiation
GO:0010842--P:retina layer formation
GO:0060042--P:retina morphogenesis in camera-type eye