dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001550
Uniprot Accession O43488; ARK72_HUMAN; O75749; Q5TG63;
Genbank Protein ID NP_003680.2;
Genbank Nucleotide ID NM_003689.3;
Protein Name Aflatoxin B1 aldehyde reductase member 2
Protein Synonyms/Alias AFB1 aldehyde reductase 1;AFB1-AR 1;Aldoketoreductase 7;Succinic semialdehyde reductase;SSA reductase;
Gene Name AKR7A2
Gene Synonyms/Alias AFAR;AFAR1;AKR7;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
40PPPPRVASVLGTMEMPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
56RRMDAPASAAAVRAFdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
78LDTAFMYSDGQSETIPhosphoSitePlus22135298
223RHFGLRFYAYNPLAGdbPTM 3.0;PhosphoSitePlus20090780; 16381945; 23193290; 22135298
225FGLRFYAYNPLAGGLdbPTM 3.0;PhosphoSitePlus20090780; 21253578; 16381945; 23193290; 22135298
255VGRFFGNSWAETYRNdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 20068231; 20166139; 22115753;
259FGNSWAETYRNRFWKPhosphoSitePlus22135298
287LQAAYGASAPSVTSAPHOSIDA21081558
Sequence
(Fasta)		MLSAASRVVS RAAVHCALRS PPPEARALAM SRPPPPRVAS VLGTMEMGRR MDAPASAAAV 60
RAFLERGHTE LDTAFMYSDG QSETILGGLG LGLGGGDCRV KIATKANPWD GKSLKPDSVR 120
SQLETSLKRL QCPQVDLFYL HAPDHGTPVE ETLHACQRLH QEGKFVELGL SNYASWEVAE 180
ICTLCKSNGW ILPTVYQGMY NATTRQVETE LFPCLRHFGL RFYAYNPLAG GLLTGKYKYE 240
DKDGKQPVGR FFGNSWAETY RNRFWKEHHF EAIALVEKAL QAAYGASAPS VTSAALRWMY 300
HHSQLQGAHG DAVILGMSSL EQLEQNLAAT EEGPLEPAVV DAFNQAWHLV AHECPNYFR 360
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0333--Golgi apparatus
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR001395--Aldo/ket_red/Kv-b
IPR023210--NADP_OxRdtase_dom
PROSITE
Pfam

PF00248--Aldo_ket_red
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0005739--C:mitochondrion
GO:0004032--F:alditol:NADP+ 1-oxidoreductase activity
GO:0009055--F:electron carrier activity
GO:0019119--F:phenanthrene-9,10-epoxide hydrolase activity
GO:0005975--P:carbohydrate metabolic process
GO:0006081--P:cellular aldehyde metabolic process
GO:0044597--P:daunorubicin metabolic process
GO:0044598--P:doxorubicin metabolic process
GO:0044281--P:small molecule metabolic process
GO:0006805--P:xenobiotic metabolic process