Tag |
Content |
dbPAF ID |
dbPAF-0001548 |
Uniprot Accession |
O43474; KLF4_HUMAN; B2R8S4; B3KT79; L0R3I6; L0R4N5; P78338; Q5T3J8; Q5T3J9; Q8N717; Q9UNP3; |
Genbank Protein ID |
NP_004226.3; |
Genbank Nucleotide ID |
NM_004235.5; |
Protein Name |
Krueppel-like factor 4 |
Protein Synonyms/Alias |
Epithelial zinc finger protein EZF;Gut-enriched krueppel-like factor; |
Gene Name |
KLF4 |
Gene Synonyms/Alias |
EZF;GKLF; |
Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.Functional Description
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
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Phosphorylation Sites
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dbPAF PTMs: 15 |
Sequence (Fasta) | MRQPPGESDM AVSDALLPSF STFASGPAGR EKTLRQAGAP NNRWREELSH MKRLPPVLPG 60 RPYDLAAATV ATDLESGGAG AACGGSNLAP LPRRETEEFN DLLDLDFILS NSLTHPPESV 120 AATVSSSASA SSSSSPSSSG PASAPSTCSF TYPIRAGNDP GVAPGGTGGG LLYGRESAPP 180 PTAPFNLADI NDVSPSGGFV AELLRPELDP VYIPPQQPQP PGGGLMGKFV LKASLSAPGS 240 EYGSPSVISV SKGSPDGSHP VVVAPYNGGP PRTCPKIKQE AVSSCTHLGA GPPLSNGHRP 300 AAHDFPLGRQ LPSRTTPTLG LEEVLSSRDC HPALPLPPGF HPHPGPNYPS FLPDQMQPQV 360 PPLHYQGQSR GFVARAGEPC VCWPHFGTHG MMLTPPSSPL ELMPPGSCMP EEPKPKRGRR 420 SWPRKRTATH TCDYAGCGKT YTKSSHLKAH LRTHTGEKPY HCDWDGCGWK FARSDELTRH 480 YRKHTGHRPF QCQKCDRAFS RSDHLALHMK RHF
514Fasta Sequence
>O43474|KLF4|Homo sapiens(Human) MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPGRPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESVAATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQVPPLHYQGQSRGFVARAGEPCVCWPHFGTHGMMLTPPSSPLELMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF
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Keyword |
KW-0010--Activator KW-0025--Alternative splicing KW-0181--Complete proteome KW-0238--DNA-binding KW-1017--Isopeptide bond KW-0479--Metal-binding KW-0539--Nucleus KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0677--Repeat KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation KW-0862--Zinc KW-0863--Zinc-finger
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Interpro |
IPR007087--Znf_C2H2 IPR015880--Znf_C2H2-like IPR013087--Znf_C2H2/integrase_DNA-bd
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PROSITE |
PS00028--ZINC_FINGER_C2H2_1 PS50157--ZINC_FINGER_C2H2_2
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Pfam |
PF00096--zf-C2H2
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Gene Ontology |
GO:0000790--C:nuclear chromatin GO:0005719--C:nuclear euchromatin GO:0044798--C:nuclear transcription factor complex GO:0005654--C:nucleoplasm GO:0001047--F:core promoter binding GO:0000987--F:core promoter proximal region sequence-specific DNA binding GO:0035014--F:phosphatidylinositol 3-kinase regulator activity GO:0001085--F:RNA polymerase II transcription factor binding GO:0003700--F:transcription factor activity, sequence-specific DNA binding GO:0001010--F:transcription factor activity, sequence-specific DNA binding transcription factor recruiting GO:0044212--F:transcription regulatory region DNA binding GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding GO:0008270--F:zinc ion binding GO:0060070--P:canonical Wnt signaling pathway GO:0071409--P:cellular response to cycloheximide GO:0071363--P:cellular response to growth factor stimulus GO:0070301--P:cellular response to hydrogen peroxide GO:0071499--P:cellular response to laminar fluid shear stress GO:1901653--P:cellular response to peptide GO:0071300--P:cellular response to retinoic acid GO:0009913--P:epidermal cell differentiation GO:0048730--P:epidermis morphogenesis GO:0045444--P:fat cell differentiation GO:0007500--P:mesodermal cell fate determination GO:0090051--P:negative regulation of cell migration involved in sprouting angiogenesis GO:0008285--P:negative regulation of cell proliferation GO:2000342--P:negative regulation of chemokine (C-X-C motif) ligand 2 production GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0070373--P:negative regulation of ERK1 and ERK2 cascade GO:0034115--P:negative regulation of heterotypic cell-cell adhesion GO:0050728--P:negative regulation of inflammatory response GO:0045415--P:negative regulation of interleukin-8 biosynthetic process GO:0014740--P:negative regulation of muscle hyperplasia GO:0032088--P:negative regulation of NF-kappaB transcription factor activity GO:0014067--P:negative regulation of phosphatidylinositol 3-kinase signaling GO:0051898--P:negative regulation of protein kinase B signaling GO:0060761--P:negative regulation of response to cytokine stimulus GO:0048662--P:negative regulation of smooth muscle cell proliferation GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0045892--P:negative regulation of transcription, DNA-templated GO:0032270--P:positive regulation of cellular protein metabolic process GO:0046985--P:positive regulation of hemoglobin biosynthetic process GO:0045429--P:positive regulation of nitric oxide biosynthetic process GO:0051247--P:positive regulation of protein metabolic process GO:0051973--P:positive regulation of telomerase activity GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0045893--P:positive regulation of transcription, DNA-templated GO:0031077--P:post-embryonic camera-type eye development GO:0035166--P:post-embryonic hemopoiesis GO:0045595--P:regulation of cell differentiation GO:0035019--P:somatic stem cell population maintenance GO:0019827--P:stem cell population maintenance GO:0006366--P:transcription from RNA polymerase II promoter
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