dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001547
Uniprot Accession O43464; HTRA2_HUMAN; Q9HBZ4; Q9P0Y3; Q9P0Y4;
Genbank Protein ID NP_037379.1; NP_659540.1;
Genbank Nucleotide ID NM_013247.4; NM_145074.2;
Protein Name Serine protease HTRA2, mitochondrial
Protein Synonyms/Alias High temperature requirement protein A2;HtrA2;Omi stress-regulated endoprotease;Serine protease 25;Serine proteinase OMI;
Gene Name HTRA2
Gene Synonyms/Alias OMI;PRSS25;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
41DLRALLTSGTSDPRAcurated20873877
51SDPRARVTYGTPSLWdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated16674116; 16381945; 23193290; 22135298; 19366988; 22817900
54RARVTYGTPSLWARLdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated16674116; 16381945; 23193290; 22135298; 19366988; 22817900
62PSLWARLSVGVTEPRcurated24888630
96DTRTREASENSGTRSPhosphoSitePlus22135298
142VPSPPPASPRSQYNFdbPTM 3.0;PhosphoSitePlus;curated17906618; 21701498; 21701785; 16381945; 23193290; 22135298;
157IADVVEKTAPAVVYIPhosphoSitePlus22135298
212RVRVRLLSGDTYEAVdbPTM 3.0;PhosphoSitePlus;curated17311912; 16381945; 23193290; 22135298; 22817900
242QTKEPLPTLPLGRSAPhosphoSitePlus22135298
326GVNTMKVTAGISFAIPhosphoSitePlus22135298
330MKVTAGISFAIPSDRPhosphoSitePlus22135298
352GEKKNSSSGISGSQRPhosphoSitePlus22135298
361ISGSQRRYIGVMMLTdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
400IHKVILGSPAHRAGLdbPTM 3.0;PhosphoSitePlus;curated17906618; 21701498; 16381945; 23193290; 22135298; 22817900
453ETLTLYVTPEVTE--PhosphoSitePlus22135298
Sequence
(Fasta)		MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV TYGTPSLWAR 60
LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG TRSRAWLAVA LGAGGAVLLL 120
LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI ADVVEKTAPA VVYIEILDRH PFLGREVPIS 180
NGSGFVVAAD GLIVTNAHVV ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKEPL 240
PTLPLGRSAD VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA 300
IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS SSGISGSQRR 360
YIGVMMLTLS PSILAELQLR EPSFPDVQHG VLIHKVILGS PAHRAGLRPG DVILAIGEQM 420
VQNAEDVYEA VRTQSQLAVQ IRRGRETLTL YVTPEVTE 459
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0068--Autocatalytic cleavage
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0378--Hydrolase
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0523--Neurodegeneration
KW-0907--Parkinson disease
KW-0908--Parkinsonism
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0720--Serine protease
KW-0809--Transit peptide
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0865--Zymogen
Interpro

IPR001478--PDZ
IPR009003--Peptidase_S1_PA
IPR001940--Peptidase_S1C
IPR001254--Trypsin_dom
PROSITE

PS50106--PDZ
Pfam

PF13180--PDZ_2
Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0000785--C:chromatin
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016020--C:membrane
GO:0005758--C:mitochondrial intermembrane space
GO:0031966--C:mitochondrial membrane
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0008233--F:peptidase activity
GO:0004252--F:serine-type endopeptidase activity
GO:0008236--F:serine-type peptidase activity
GO:0051082--F:unfolded protein binding
GO:0007628--P:adult walking behavior
GO:0044257--P:cellular protein catabolic process
GO:0071363--P:cellular response to growth factor stimulus
GO:0034605--P:cellular response to heat
GO:0035458--P:cellular response to interferon-beta
GO:0034599--P:cellular response to oxidative stress
GO:0071300--P:cellular response to retinoic acid
GO:0006672--P:ceramide metabolic process
GO:0097194--P:execution phase of apoptosis
GO:0030900--P:forebrain development
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0007005--P:mitochondrion organization
GO:0045786--P:negative regulation of cell cycle
GO:1901215--P:negative regulation of neuron death
GO:1902176--P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0048666--P:neuron development
GO:0019742--P:pentacyclic triterpenoid metabolic process
GO:0043065--P:positive regulation of apoptotic process
GO:0010942--P:positive regulation of cell death
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001269--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:2001241--P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016540--P:protein autoprocessing
GO:0006508--P:proteolysis
GO:1903146--P:regulation of mitophagy
GO:0040014--P:regulation of multicellular organism growth
GO:0009635--P:response to herbicide