| Tag |
Content |
| dbPAF ID |
dbPAF-0001546 |
| Uniprot Accession |
O43463; SUV91_HUMAN; B2R6E8; B4DST0; Q53G60; Q6FHK6;
|
| Genbank Protein ID |
NP_001269095.1; NP_003164.1;
|
| Genbank Nucleotide ID |
NM_001282166.1; NM_003173.3;
|
| Protein Name |
Histone-lysine N-methyltransferase SUV39H1 |
| Protein Synonyms/Alias |
Histone H3-K9 methyltransferase 1;H3-K9-HMTase 1;Lysine N-methyltransferase 1A;Position-effect variegation 3-9 homolog;Suppressor of variegation 3-9 homolog 1;Su(var)3-9 homolog 1; |
| Gene Name |
SUV39H1 |
| Gene Synonyms/Alias |
KMT1A;SUV39H; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.Functional Description
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MAENLKGCSV CCKSSWNQLQ DLCRLAKLSC PALGISKRNL YDFEVEYLCD YKKIREQEYY 60
LVKWRGYPDS ESTWEPRQNL KCVRILKQFH KDLERELLRR HHRSKTPRHL DPSLANYLVQ 120
KAKQRRALRR WEQELNAKRS HLGRITVENE VDLDGPPRAF VYINEYRVGE GITLNQVAVG 180
CECQDCLWAP TGGCCPGASL HKFAYNDQGQ VRLRAGLPIY ECNSRCRCGY DCPNRVVQKG 240
IRYDLCIFRT DDGRGWGVRT LEKIRKNSFV MEYVGEIITS EEAERRGQIY DRQGATYLFD 300
LDYVEDVYTV DAAYYGNISH FVNHSCDPNL QVYNVFIDNL DERLPRIAFF ATRTIRAGEE 360
LTFDYNMQVD PVDMESTRMD SNFGLAGLPG SPKKRVRIEC KCGTESCRKY LF
413Fasta Sequence
>O43463|SUV39H1|Homo sapiens(Human)
MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0945--Host-virus interaction
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0698--rRNA processing
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
|
| Interpro |
IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
IPR011381--Histone_H3-K9_MeTrfase
IPR003616--Post-SET_dom
IPR007728--Pre-SET_dom
IPR003606--Pre-SET_Zn-bd_sub
IPR001214--SET_dom
|
| PROSITE |
PS00598--CHROMO_1
PS50013--CHROMO_2
PS50868--POST_SET
PS50867--PRE_SET
PS51579--SAM_MT43_SUVAR39_3
PS50280--SET
|
| Pfam |
PF00385--Chromo
PF05033--Pre-SET
PF00856--SET
|
| Gene Ontology |
GO:0005677--C:chromatin silencing complex
GO:0000775--C:chromosome, centromeric region
GO:0000794--C:condensed nuclear chromosome
GO:0000792--C:heterochromatin
GO:0005652--C:nuclear lamina
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0033553--C:rDNA heterochromatin
GO:0003682--F:chromatin binding
GO:0042054--F:histone methyltransferase activity
GO:0046974--F:histone methyltransferase activity (H3-K9 specific)
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0047485--F:protein N-terminus binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0008757--F:S-adenosylmethionine-dependent methyltransferase activity
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0030154--P:cell differentiation
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071456--P:cellular response to hypoxia
GO:0006325--P:chromatin organization
GO:0000183--P:chromatin silencing at rDNA
GO:0010467--P:gene expression
GO:0036123--P:histone H3-K9 dimethylation
GO:0036124--P:histone H3-K9 trimethylation
GO:0042754--P:negative regulation of circadian rhythm
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0040029--P:regulation of gene expression, epigenetic
GO:0001975--P:response to amphetamine
GO:0031667--P:response to nutrient levels
GO:0048511--P:rhythmic process
GO:0006364--P:rRNA processing
GO:0006351--P:transcription, DNA-templated
GO:0016032--P:viral process
|
