dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001545
Uniprot Accession O43462; MBTP2_HUMAN; Q9UM70; Q9UMD3;
Genbank Protein ID NP_056968.1;
Genbank Nucleotide ID NM_015884.3;
Protein Name Membrane-bound transcription factor site-2 protease
Protein Synonyms/Alias Endopeptidase S2P;Sterol regulatory element-binding proteins intramembrane protease;SREBPs intramembrane protease;
Gene Name MBTPS2
Gene Synonyms/Alias S2P;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
116SPSSYSSSSSSSSSSPhosphoSitePlus22135298
117PSSYSSSSSSSSSSSPhosphoSitePlus22135298
118SSYSSSSSSSSSSSSPhosphoSitePlus22135298
119SYSSSSSSSSSSSSSPhosphoSitePlus22135298
120YSSSSSSSSSSSSSSPhosphoSitePlus22135298
125SSSSSSSSSSSSSSSPhosphoSitePlus22135298
126SSSSSSSSSSSSSSSPhosphoSitePlus22135298
127SSSSSSSSSSSSSSSPhosphoSitePlus22135298
265ITEVAEDSPAIGPRGPhosphoSitePlus22135298
Sequence
(Fasta)		MIPVSLVVVV VGGWTVVYLT DLVLKSSVYF KHSYEDWLEN NGLSISPFHI RWQTAVFNRA 60
FYSWGRRKAR MLYQWFNFGM VFGVIAMFSS FFLLGKTLMQ TLAQMMADSP SSYSSSSSSS 120
SSSSSSSSSS SSSSSSLHNE QVLQVVVPGI NLPVNQLTYF FTAVLISGVV HEIGHGIAAI 180
REQVRFNGFG IFLFIIYPGA FVDLFTTHLQ LISPVQQLRI FCAGIWHNFV LALLGILALV 240
LLPVILLPFY YTGVGVLITE VAEDSPAIGP RGLFVGDLVT HLQDCPVTNV QDWNECLDTI 300
AYEPQIGYCI SASTLQQLSF PVRAYKRLDG STECCNNHSL TDVCFSYRNN FNKRLHTCLP 360
ARKAVEATQV CRTNKDCKKS SSSSFCIIPS LETHTRLIKV KHPPQIDMLY VGHPLHLHYT 420
VSITSFIPRF NFLSIDLPVV VETFVKYLIS LSGALAIVNA VPCFALDGQW ILNSFLDATL 480
TSVIGDNDVK DLIGFFILLG GSVLLAANVT LGLWMVTAR
Keyword

KW-0153--Cholesterol metabolism
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0977--Ichthyosis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-1007--Palmoplantar keratoderma
KW-0645--Protease
KW-1185--Reference proteome
KW-0753--Steroid metabolism
KW-1207--Sterol metabolism
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
Interpro

IPR001193--MBTPS2
IPR001478--PDZ
IPR008915--Peptidase_M50
PROSITE

PS00142--ZINC_PROTEASE
Pfam

PF02163--Peptidase_M50
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0046872--F:metal ion binding
GO:0004222--F:metalloendopeptidase activity
GO:0036500--P:ATF6-mediated unfolded protein response
GO:0044267--P:cellular protein metabolic process
GO:0008203--P:cholesterol metabolic process
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0031293--P:membrane protein intracellular domain proteolysis
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:1990440--P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0034976--P:response to endoplasmic reticulum stress
GO:0044281--P:small molecule metabolic process