dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001544
Uniprot Accession O43451; MGA_HUMAN; Q0VAX6; Q75ME7; Q86UM5;
Genbank Protein ID NP_004659.2;
Genbank Nucleotide ID NM_004668.2;
Protein Name Maltase-glucoamylase, intestinal
Protein Synonyms/Alias
Gene Name MGAM
Gene Synonyms/Alias MGA;MGAML;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
10RKKLKKFTTLEIVLSdbPTM 3.0;HPRD 9;PhosphoSitePlus20166139; 16381945; 23193290; 18988627; 22135298
17TTLEIVLSVLLLVLFdbPTM 3.0;HPRD 9;PhosphoSitePlus20166139; 16381945; 23193290; 18988627; 22135298
27LLVLFIISIVLIVLLdbPTM 3.0;HPRD 9;PhosphoSitePlus20166139; 16381945; 23193290; 18988627; 22135298
385LGFHLSRYEYGTLDNPhosphoSitePlus22135298
389LSRYEYGTLDNMREVPhosphoSitePlus22135298
461AISNNSSSSKPYGPYPhosphoSitePlus22135298
618TRSTFAGSGKFAAHWPhosphoSitePlus22135298
712LLNSSRHYLNIRYTLPhosphoSitePlus22135298
1172NSYGVHPYYMGLEEDPhosphoSitePlus22135298
1173SYGVHPYYMGLEEDGPhosphoSitePlus22135298
1613RTVLQTRYTLLPYLYPhosphoSitePlus22135298
1620YTLLPYLYTLMHKAHPhosphoSitePlus22135298
1621TLLPYLYTLMHKAHTPhosphoSitePlus22135298
1683YFPRARWYDYYTGVDPhosphoSitePlus22135298
1685PRARWYDYYTGVDINPhosphoSitePlus22135298
1686RARWYDYYTGVDINAPhosphoSitePlus22135298
1687ARWYDYYTGVDINARPhosphoSitePlus22135298
Sequence
(Fasta)		MARKKLKKFT TLEIVLSVLL LVLFIISIVL IVLLAKESLK STAPDPGTTG TPDPGTTGTP 60
DPGTTGTTHA RTTGPPDPGT TGTTPVSAEC PVVNELERIN CIPDQPPTKA TCDQRGCCWN 120
PQGAVSVPWC YYSKNHSYHV EGNLVNTNAG FTARLKNLPS SPVFGSNVDN VLLTAEYQTS 180
NRFHFKLTDQ TNNRFEVPHE HVQSFSGNAA ASLTYQVEIS RQPFSIKVTR RSNNRVLFDS 240
SIGPLLFADQ FLQLSTRLPS TNVYGLGEHV HQQYRHDMNW KTWPIFNRDT TPNGNGTNLY 300
GAQTFFLCLE DASGLSFGVF LMNSNAMEVV LQPAPAITYR TIGGILDFYV FLGNTPEQVV 360
QEYLELIGRP ALPSYWALGF HLSRYEYGTL DNMREVVERN RAAQLPYDVQ HADIDYMDER 420
RDFTYDSVDF KGFPEFVNEL HNNGQKLVII VDPAISNNSS SSKPYGPYDR GSDMKIWVNS 480
SDGVTPLIGE VWPGQTVFPD YTNPNCAVWW TKEFELFHNQ VEFDGIWIDM NEVSNFVDGS 540
VSGCSTNNLN NPPFTPRILD GYLFCKTLCM DAVQHWGKQY DIHNLYGYSM AVATAEAAKT 600
VFPNKRSFIL TRSTFAGSGK FAAHWLGDNT ATWDDLRWSI PGVLEFNLFG IPMVGPDICG 660
FALDTPEELC RRWMQLGAFY PFSRNHNGQG YKDQDPASFG ADSLLLNSSR HYLNIRYTLL 720
PYLYTLFFRA HSRGDTVARP LLHEFYEDNS TWDVHQQFLW GPGLLITPVL DEGAEKVMAY 780
VPDAVWYDYE TGSQVRWRKQ KVEMELPGDK IGLHLRGGYI FPTQQPNTTT LASRKNPLGL 840
IIALDENKEA KGELFWDNGE TKDTVANKVY LLCEFSVTQN RLEVNISQST YKDPNNLAFN 900
EIKILGTEEP SNVTVKHNGV PSQTSPTVTY DSNLKVAIIT DIDLLLGEAY TVEWSIKIRD 960
EEKIDCYPDE NGASAENCTA RGCIWEASNS SGVPFCYFVN DLYSVSDVQY NSHGATADIS 1020
LKSSVYANAF PSTPVNPLRL DVTYHKNEML QFKIYDPNKN RYEVPVPLNI PSMPSSTPEG 1080
QLYDVLIKKN PFGIEIRRKS TGTIIWDSQL LGFTFSDMFI RISTRLPSKY LYGFGETEHR 1140
SYRRDLEWHT WGMFSRDQPP GYKKNSYGVH PYYMGLEEDG SAHGVLLLNS NAMDVTFQPL 1200
PALTYRTTGG VLDFYVFLGP TPELVTQQYT ELIGRPVMVP YWSLGFQLCR YGYQNDSEIA 1260
SLYDEMVAAQ IPYDVQYSDI DYMERQLDFT LSPKFAGFPA LINRMKADGM RVILILDPAI 1320
SGNETQPYPA FTRGVEDDVF IKYPNDGDIV WGKVWPDFPD VVVNGSLDWD SQVELYRAYV 1380
AFPDFFRNST AKWWKREIEE LYNNPQNPER SLKFDGMWID MNEPSSFVNG AVSPGCRDAS 1440
LNHPPYMPHL ESRDRGLSSK TLCMESQQIL PDGSLVQHYN VHNLYGWSQT RPTYEAVQEV 1500
TGQRGVVITR STFPSSGRWA GHWLGDNTAA WDQLKKSIIG MMEFSLFGIS YTGADICGFF 1560
QDAEYEMCVR WMQLGAFYPF SRNHNTIGTR RQDPVSWDVA FVNISRTVLQ TRYTLLPYLY 1620
TLMHKAHTEG VTVVRPLLHE FVSDQVTWDI DSQFLLGPAF LVSPVLERNA RNVTAYFPRA 1680
RWYDYYTGVD INARGEWKTL PAPLDHINLH VRGGYILPWQ EPALNTHLSR QKFMGFKIAL 1740
DDEGTAGGWL FWDDGQSIDT YGKGLYYLAS FSASQNTMQS HIIFNNYITG TNPLKLGYIE 1800
IWGVGSVPVT SVSISVSGMV ITPSFNNDPT TQVLSIDVTD RNISLHNFTS LTWISTL 1858
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0326--Glycosidase
KW-0378--Hydrolase
KW-0472--Membrane
KW-0511--Multifunctional enzyme
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0735--Signal-anchor
KW-0765--Sulfation
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR031727--Gal_mutarotase_N
IPR011013--Gal_mutarotase_SF_dom
IPR000322--Glyco_hydro_31
IPR030458--Glyco_hydro_31_AS
IPR030459--Glyco_hydro_31_CS
IPR017853--Glycoside_hydrolase_SF
IPR017957--P_trefoil_CS
IPR000519--P_trefoil_dom
PROSITE

PS00129--GLYCOSYL_HYDROL_F31_1
PS00707--GLYCOSYL_HYDROL_F31_2
PS00025--P_TREFOIL_1
PS51448--P_TREFOIL_2
Pfam

PF01055--Glyco_hydro_31
PF16863--NtCtMGAM_N
PF00088--Trefoil
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0004558--F:alpha-1,4-glucosidase activity
GO:0016160--F:amylase activity
GO:0030246--F:carbohydrate binding
GO:0003824--F:catalytic activity
GO:0004339--F:glucan 1,4-alpha-glucosidase activity
GO:0032450--F:maltose alpha-glucosidase activity
GO:0005975--P:carbohydrate metabolic process
GO:0044245--P:polysaccharide digestion
GO:0044281--P:small molecule metabolic process
GO:0005983--P:starch catabolic process